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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 417 - 423 (7page)
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초록· 키워드
오류제보하기
Objective Since the risk of suicide cannot be predicted by clinical symptoms alone, and suicide is known to have a genetic component, the discovery of genetic markers that can predict the lethality of suicide attempts is a clinically important topic. There have been many studies aiming to determine whether the rs6265 polymorphism of the BDNF gene is associated with suicidality; however, the results have been mixed, and there have been few studies investigating the relationship between this polymorphism and suicide attempt lethality. Methods We assessed suicide lethality in 258 individuals who had attempted suicide using the relative risk ratio (RRR) scale and by genotyping the rs6265 polymorphism of the BDNF gene. Results The RRR score for suicide attempts was higher in subjects with Met/Val and Val/Val genotypes than in that with a Met/Met genotype (p=0.015). The RRR score for suicide attempts was also higher in Val allele carriers (Met/Val+Val/Val) than in Met/Met homozygotes (p=0.006). Conclusion This study demonstrates the possibility that the rs6265 polymorphism of the BDNF gene could be used as a genetic marker to predict the lethality of suicide attempts, but more replication studies are needed for the application of this result in clinical practice.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Statistics Korea / 2017 / Annual Report of the Cause of Death Statistics
Mirkovic B / 2016 / Genetic association studies of suicidal behavior : a review of the past 10 years, progress, limitations, and future directions / Front Psychiatry 7:158
Maisonpierre PC / 1991 / Human and rat brain-derived neurotrophic factor and neurotrophin-3 : gene structures, distributions, and chromosomal localizations / Genomics 10:558~568
Webster MJ / 2002 / BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex / Brain Res Dev Brain Res 139:139~150
Sears C / 2013 / Investigating the role of BDNF and CCK system genes in suicidality in a familial bipolar cohort / J Affect Disord 151:611~617
Mirkovic B / 2016 / Genetic association studies of suicidal behavior : a review of the past 10 years, progress, limitations, and future directions / Front Psychiatry 7:158
Maisonpierre PC / 1991 / Human and rat brain-derived neurotrophic factor and neurotrophin-3 : gene structures, distributions, and chromosomal localizations / Genomics 10:558~568
Webster MJ / 2002 / BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex / Brain Res Dev Brain Res 139:139~150
Sears C / 2013 / Investigating the role of BDNF and CCK system genes in suicidality in a familial bipolar cohort / J Affect Disord 151:611~617
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