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Background: The purpose of this study is to compare the skeletal stability of two-jaw surgery via surgery-firstapproach with conventional two-jaw surgery in facial asymmetry patients by measuring the skeletal changes aftersurgery from a three-dimensional analysis. From January 2010 to January 2014, 40 patients with facial asymmetrywho underwent two-jaw surgery in Pusan National University Hospital were included in this study. They wereclassified into experimental group (n = 20) who underwent two-jaw surgery via surgery-first approach and controlgroup (n = 20) who underwent conventional two-jaw surgery. After selection of 24 landmarks and the constructionof horizontal and sagittal, coronal reference planes, changes in 10 linear measurements and 2 angular measurementswere compared between the surgery-first approach and conventional groups in the preoperative, immediatepostoperative, and postoperative periods. The paired t test and Student t test were used for statistical analysis. Themean and standard deviation of the measurement were calculated for the experimental and control groups. Results: The statistical analysis showed that changes in skeletal measurements were similar between the surgery-firstapproach and conventional groups, according to each period. However, U1-SRP measurement showed statisticallysignificant changes in surgery-first approach groups at postsurgical change (T1 to T2). Also, the mean treatmentduration in the treatment group was 15.9 ± 5.48 months whereas that in the control group was 32.9 ± 14.05 months. Conclusion: In facial asymmetry patients, similar results were observed in the postoperative skeletal stability when 2-jaw surgery via surgery-first approach was compared with conventional 2-jaw surgery. However, significant lateraldeviation of upper incisor midline was observed. In addition, a shorter average treatment duration was observed. Tostabilize the unstable occlusion after surgery, increased wearing of the stent and proactive rubber guidance will beneeded.

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