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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 855 - 866 (12page)
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Purpose The prognosis of nasopharyngeal carcinoma (NPC) patients with parotid lymph node (PLN) metastasis remains unclear. This study was performed to investigate the prognostic significance and optimal staging category of PLN metastasis and develop a nomogram for estimating individual risk. Materials and Methods Clinical data of 7,084 non-metastatic NPC patients were retrospectively reviewed. Overall survival (OS) was the primary endpoint. A nomogram was established based on the Cox proportional hazards regression model. The accuracy and calibration ability of this nomogram was evaluated by C-index and calibration curves with bootstrap validation. Results Totally, 164/7,084 NPC patients (2.3%) presented with PLNs. Multivariate analyses showed that PLN metastasis was a negative prognostic factor for OS, progression-free survival (PFS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRFS). Patients with PLN metastasis had a worse prognosis than N3 disease. Five independent prognostic factors were included in the nomogram, which showed a C-index of 0.743. The calibration curves for probability of 3- and 5-year OS indicated satisfactory agreement between nomogram-based prediction and actual observation. All results were confirmed in the validation cohort. Conclusion NPC patient with PLN metastasis had poorer survival outcome (OS, PFS, DMFS, and LRFS) than N3 disease. We developed a nomogram to provide individual prediction of OS for patients with PLN metastasis.
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참고문헌 (30)
참고문헌 신청
Cao SM / 2011 / The prevalence and prevention of nasopharyngeal carcinoma in China / Chin J Cancer 30:114~119
Simons MJ / 2010 / The origin of genetic risk for nasopharyngeal carcinoma : a commentary on : is nasopharyngeal cancer really a"Cantonese cancer" / Chin J Cancer 29:527~537
Ho FC / 2012 / Patterns of regional lymph node metastasis of nasopharyngeal carcinoma : a meta-analysis of clinical evidence / BMC Cancer 12:98
Tang L / 2009 / The volume to be irradiated during selective neck irradiation in nasopharyngeal carcinoma : analysis of the spread patterns in lymph nodes by magnetic resonance imaging / Cancer 115:680~688
King AD / 2000 / Neck node metastases from nasopharyngeal carcinoma : MR imaging of patterns of disease / Head Neck 22:275~281
Simons MJ / 2010 / The origin of genetic risk for nasopharyngeal carcinoma : a commentary on : is nasopharyngeal cancer really a"Cantonese cancer" / Chin J Cancer 29:527~537
Ho FC / 2012 / Patterns of regional lymph node metastasis of nasopharyngeal carcinoma : a meta-analysis of clinical evidence / BMC Cancer 12:98
Tang L / 2009 / The volume to be irradiated during selective neck irradiation in nasopharyngeal carcinoma : analysis of the spread patterns in lymph nodes by magnetic resonance imaging / Cancer 115:680~688
King AD / 2000 / Neck node metastases from nasopharyngeal carcinoma : MR imaging of patterns of disease / Head Neck 22:275~281
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