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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 312 - 316 (5page)
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초록· 키워드
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Angiogenesis is important for the proliferation and survival of multiple myeloma (MM) cells. Bone marrow (BM) microvessel density (MVD) is a useful marker of angiogenesis and an increase in MVD can be used as a marker of poor prognosis in MM patients. We developed an automated image analyzer to assess MVD from images of BM biopsies stained with anti-CD34 antibodies using two color models. MVD was calculated by merging images from the red and hue channels after eliminating non-microvessels. The analyzer results were compared with those obtained by two experienced hematopathologists in a blinded manner using the 84 BM samples of MM patients. Manual assessment of the MVD by two hematopathologists yielded mean±SD values of 19.4±11.8 and 20.0±11.8. The analyzer generated a mean±SD of 19.5±11.2. The intraclass correlation coefficient (ICC) and Bland-Altman plot of the MVD results demonstrated very good agreement between the automated image analyzer and both hematopathologists (ICC=0.893 [0.840–0.929] and ICC=0.906 [0.859–0.938]). This automated analyzer can provide time- and labor-saving benefits with more objective results in hematology laboratories.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Bergers G / 2003 / Tumorigenesis and the angiogenic switch / Nat Rev Cancer 3:401~410
Uzzan B / 2004 / Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis / Cancer Res 64:2941~2955
Galindo-Gallego M / 2000 / Prognostic significance of microvascular counts in rectal carcinoma / Pathol Res Pract 196:607~612
Graham CH / 1994 / Extent of vascularization as a prognostic indicator in thin (< 0.76 mm) malignant melanomas / Am J Pathol 145:510~514
Hussong JW / 2000 / Evidence of increased angiogenesis in patients with acute myeloid leukemia / Blood 95:309~313
Uzzan B / 2004 / Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis / Cancer Res 64:2941~2955
Galindo-Gallego M / 2000 / Prognostic significance of microvascular counts in rectal carcinoma / Pathol Res Pract 196:607~612
Graham CH / 1994 / Extent of vascularization as a prognostic indicator in thin (< 0.76 mm) malignant melanomas / Am J Pathol 145:510~514
Hussong JW / 2000 / Evidence of increased angiogenesis in patients with acute myeloid leukemia / Blood 95:309~313
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