지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제50권 제3호
- 발행연도
- 2020.1
- 수록면
- 159 - 170 (12page)
이용수
초록· 키워드
오류제보하기
Purpose: Immunization with Porphyromonas gingivalis heat shock protein 60 (PgHSP60) may have an immunoregulatory effect on atherogenesis. The aim of this study was to determine whether nasal immunization with a PgHSP60 peptide could reduce atherosclerotic plaque formation in apolipoprotein E knockout (ApoE KO) mice. Methods: Seven-week-old male ApoE KO mice were assigned to receive a normal diet, a Western diet, a Western diet and challenge with PgHSP60-derived peptide 14 (Pep14) or peptide 19 (Pep19), or a Western diet and immunization with Pep14 or Pep19 before challenge with Pep14 or Pep19. Results: Atherosclerotic plaques were significantly smaller in mice that received a Western diet with Pep14 nasal immunization than in mice that received a Western diet and no Pep14 immunization with or without Pep14 challenge. An immunoblot profile failed to detect serum reactivity to Pep14 in any of the study groups. Stimulation by either Pep14 or Pep19 strongly promoted the induction of CD4+ CD25+ forkhead box P3 (FoxP3)+ human regulatory T cells (Tregs) in vitro. However, the expression of mouse splenic CD4+ CD25+ FoxP3+ Tregs was lower in the Pep14-immunized mice than in the Pep14-challenged or Pep19-immunized mice. Levels of serum interferon gamma (IFN-γ) and transforming growth factor beta were higher and levels of interleukin (IL) 10 were lower in the Pep14-immunized mice than in the other groups. Induction of CD25− IL-17+ T helper 17 (Th17) cells was attenuated in the Pep14-immunized mice. Conclusions: Nasal immunization with Pep14 may be a mechanism for attenuating atherogenesis by promoting the secretion of IFN-γ and/or suppressing Th17-mediated immunity.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Korean Red Ginseng enhances pneumococcal Δpep27 vaccine efficacy by inhibiting reactive oxygen species production
Journal of Ginseng Research
2019 .04
-
Synergistic effect of independent risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis: a multicenter retrospective study in Japan
Clinical Endoscopy
2024 .07
-
The role of rectal diclofenac and aggressive hydration with Ringer's lactate in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients
International Journal of Gastrointestinal Intervention
2023 .04
-
The pneumococcal pep27 mutant infection enhances intracellular uptake and immune mediation, and provides apoptosis resistance via Mcl-1 upregulation in Raw264.7 cells
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Robust immunoreactivity of teenager sera against peptide 19 from Porphyromonas gingivalis HSP60
Journal of Periodontal & Implant Science
2017 .06
-
내시경 역행성 담췌관조영술 시행 후 발생하는 급성 췌장염의 예방: 내시경 시술적 관점
대한췌담도학회지
2015 .01
-
디지털 세대의 자기 대화(Self-talk)와 응원 메시지(Pep-talk): 모바일을 통한 기분 조절과 정서적 안녕
기본간호학회지
2022 .08
-
Cosmetic outcomes of simple facial laceration suturing in the pediatric emergency department
대한소아응급의학회지
2024 .04
-
Epidemiology of Animal Bites and Factors Associated With Delays in Initiating Post-exposure Prophylaxis for Rabies Prevention Among Animal Bite Cases: A Population-based Study
예방의학회지
2017 .01
-
Double-guidewire technique for selective biliary cannulation does not increase the rate of post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with naïve papilla
Clinical Endoscopy
2024 .03
-
Targeting the epitope spreader Pep19 by naïve human CD45RA+ regulatory T cells dictates a distinct suppressive T cell fate in a novel form of immunotherapy
Journal of Periodontal & Implant Science
2017 .01
-
Preventive effect of tacrolimus on patients with post- endoscopic retrograde cholangiopancreatography pancreatitis
Clinical Endoscopy
2022 .09
-
Dendritic Cells Induce Specific Cytotoxic T Lymphocytes against Prostate Cancer TRAMP-C2 Cells Loaded with Freeze-thaw Antigen and PEP-3 Peptide
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Role of vitamin C and rectal indomethacin in preventing and alleviating post-endoscopic retrograde cholangiopancreatography pancreatitis: a clinical study
Clinical Endoscopy
2023 .03
-
Psychoeducational Profile-Revised, Korean Wechsler Preschool and Primary Scale of Intelligence, Fourth Edition, and the Vineland Adaptive Behavior Scale, Second Edition: Comparison of Utility for Developmental Disabilities in Preschool Children
소아청소년정신의학
2023 .10
-
내시경역행담췌관조영술 이후 발생하는 급성 췌장염의 약물 예방요법
대한췌담도학회지
2021 .01
-
Improved Efficacy of a Dendritic Cell-Based Vaccine against a Murine Model of Colon Cancer: The Helper Protein Effect
Cancer Research and Treatment
2015 .01
-
Increased Risk of Pancreatitis after Endoscopic Retrograde Cholangiopancreatography Following a Positive Intraoperative Cholangiogram: A Single-Center Experience
Clinical Endoscopy
2021 .01
-
The effect of Yukjabaegi (six bit song) on overcoming grief through empathy sung by Hyang-ryun An pepped us up on YouTube (https://youtu.be/04RRMyOGW90)
셀메드
2016 .11
-
Response to “Adult Immunization Policy in Korea”
Infection and Chemotherapy
2024 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0