지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 3 - 12 (10page)
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초록· 키워드
오류제보하기
Neuropathic pain after spinal cord injury (SCI) has a significant negative impact on the patients’ quality of life. The objective of this systematic review is to examine the safety and efficacy of pregabalin (PGB) and gabapentin (GBP) in the treatment of neuropathic pain due to SCI. PubMed, the Cochrane Library, Embase, Scopus, and the Web of Science were searched up to December 2018. The reference lists of key and review studies were reviewed for additional citations. The quality of the studies was evaluated using the Cochrane Collaboration’s tools for assessing the risk of bias. A meta-analysis was performed for primary and secondary outcomes. Eight studies were eligible for inclusion. Meta-analysis of PGB vs. placebo showed that PGB was effective for neuropathic pain (standardized mean difference [SMD] = –0.40; 95% confidence interval [CI]: –0.78, –0.01), anxiety (MD = –0.68; 95% CI: –0.77, –0.59), depression (mean difference [MD] = –0.99; 95% CI: –1.08, –0.89), and sleep interference (MD = –1.08; 95% CI: –1.13, –1.02). Also, GBP was more effective than a placebo for reducing pain. No significant difference was observed between the efficacy of the two drugs (MD = –0.37; 95% CI: –1.67, 0.93). There was no significant difference between the two drugs for discontinuation due to adverse events (risk ratio = 3.00; 95% CI: 0.81, 11.15). PGB and GBP were effective vs. placebos in decreasing neuropathic pain after SCI. Also, there was no significant difference between the two drugs for decreasing pain and adverse events.
목차
등록된 정보가 없습니다.
참고문헌 (54)
참고문헌 신청
Sanjay Vasant Kamble / 2017 / Low doses of amitriptyline, pregabalin, and gabapentin are preferred for management of neuropathic pain in India: is there a need for revisiting dosing recommendations? / The Korean Journal of Pain 30(3):183~191
Werhagen L / 2004 / Neuropathic pain after traumatic spinal cord injury--relations to gender, spinal level, completeness, and age at the time of injury / Spinal Cord 42:665~673
Castro MM / 2009 / Sleep patterns and symptoms of anxiety and depression in patients with chronic pain / Arq Neuropsiquiatr 67:25~28
Gore M / 2005 / Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep / J Pain Symptom Manage 30:374~385
Gormsen L / 2010 / Depression, anxiety, health-related quality of life and pain in patients with chronic fibromyalgia and neuropathic pain / Eur J Pain 14:127.e1~8
Werhagen L / 2004 / Neuropathic pain after traumatic spinal cord injury--relations to gender, spinal level, completeness, and age at the time of injury / Spinal Cord 42:665~673
Castro MM / 2009 / Sleep patterns and symptoms of anxiety and depression in patients with chronic pain / Arq Neuropsiquiatr 67:25~28
Gore M / 2005 / Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep / J Pain Symptom Manage 30:374~385
Gormsen L / 2010 / Depression, anxiety, health-related quality of life and pain in patients with chronic fibromyalgia and neuropathic pain / Eur J Pain 14:127.e1~8
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