인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 저자정보
초록·키워드
Background Highly specific biologically active nucleoside and small peptides, sub fragments of collagen, in specific sequences, have attracted increasing attention for their use in the cosmeceutical field. To be effective in improving the skin and treating skin conditions, it is crucial for these cosmetic ingredients to be delivered through the epidermis and into the viable dermis. Area covered In this review, skin permeation, metabolism and clinical efficacy evaluation studies with microneedle application on adenosine and collagen sub fragments peptides, such as GHK and KTTKS were discussed. Strategies to counteract fragile and rapid clearance of nucleoside and peptides, such as specific peptide derivatives resistant to protease activity, peptide polymer conjugation, polymer encapsulated peptide delivery system incorporated within microneedles, were also discussed. Expert opinion In recent years, various types of microneedle systems such as self-dissolving hyaluronic acid microneedle and pre-treat micro array have been introduced for peptides to traverse the epidermis and into the subcutaneous layer by passive permeation. Microneedle approach can bypass stratum corneum that is a major diffusion barrier to peptides, and has offered a potentially revolutionary advance in cosmeceutical application. However, to support claimed benefits of microneedle application, advanced strategies to counteract degradation of nucleoside and peptides in the skin are required.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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