지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: Prevention of osteoporosis and bone fracture is one of the important issues for liver transplant recipients because a long history of liver disease and lifelong use of immunosuppressants, including corticosteroids, may cause these diseases. In this study, we aimed to analyze liver recipient bone status, 10-year fracture risk, and medication history. Methods: The electronic medical records of adult patients aged >40 years who received liver transplantation at Seoul National University Bundang Hospital between January 2009 and June 2017 were reviewed retrospectively. On the basis of their bone mineral density and fracture history, their fracture risks were analyzed using the Korean fracture risk assessment tool. Results:A total of 57 liver transplant recipients were treated with corticosteroids during a mean of 8.8 months after transplantation. 30 patients (52.6%) showed bone metabolism dysfunction such as osteopenia or osteoporosis. The 10-year femoral fracture risk was 2.1%, and dual-energy X-ray absorptiometry monitoring was performed, including right before liver transplantation every 27.5±19.2 months. The mean femoral bone mineral density decreased by −7.2%±7.3%. Four patients (7.0%) had a fracture after liver transplantation. Osteoporotic fracture occurred in 3 patients with osteoporosis (25.0%). Among the osteopenia patients with moderate fracture risk who were not treated with bisphosphonate, 1 patient (12.5%) had a history of bone fracture after liver transplantation. Conclusion: Considering the deterioration of bone density and moderate fracture risk, medication for osteoporosis should be prescribed to liver transplant recipients with regular monitoring of bone density after transplantation.
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참고문헌 (24)
참고문헌 신청
Lee Y / 2011 / Post-transplantation osteoporosis / J Korean Soc Transplant 25(4):239~244
Desai R / 2008 / Quality of life up to 30years following liver transplantation / Liver Transpl 14(10):1473~1479
Sheiner PA / 2000 / Long-term medical complications in patients surviving > or =5 years after liver transplant / Transplantation 69(5):781~789
Navasa M / 1996 / Quality of life, major medical complications and hospital service utilization in patients with primary biliary cirrhosis after liver transplantation / J hepatol 25(2):129~134
van Staa TP / 2000 / Oral corticosteroids and fracture risk : relationship to daily and cumulative doses / Rheumatology 39(12):1383~1389
Desai R / 2008 / Quality of life up to 30years following liver transplantation / Liver Transpl 14(10):1473~1479
Sheiner PA / 2000 / Long-term medical complications in patients surviving > or =5 years after liver transplant / Transplantation 69(5):781~789
Navasa M / 1996 / Quality of life, major medical complications and hospital service utilization in patients with primary biliary cirrhosis after liver transplantation / J hepatol 25(2):129~134
van Staa TP / 2000 / Oral corticosteroids and fracture risk : relationship to daily and cumulative doses / Rheumatology 39(12):1383~1389
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