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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 294 - 301 (8page)
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Purpose: To investigate the efficacy and safety of 0.4 mg of tamsulosin in patients with nocturia not responding to 0.2 mg. Methods: Patients with intractable nocturia after treatment with 0.2 mg of tamsulosin for>1 month were included in a multicenter, prospective, observational, single-arm study. Patients were prescribed 0.4 mg of tamsulosin and followed up for 2 months to assess nocturnal voiding and nocturia-related bother. Changes in the mean number of nocturnal voids, the proportion of 50% responders, 3-day frequency-volume chart parameters, and questionnaire scores were assessed. Results: Sixty-two patients were prescribed 0.2 mg of tamsulosin, of whom 56 were prescribed 0.4 mg of tamsulosin. Ten patients dropped out. A single case of orthostatic hypotension was reported. The mean age was 68 years. After 1 and 2 months of taking 0.4 mg of tamsulosin, 23.9% and 22.7% of patients demonstrated a>50% reduction of nocturia, and 16.1% and 19.4% of patients rated the treatment as “very effective,” respectively. Dose escalation to 0.4 mg of tamsulosin, compared to 0.2 mg, did not show an additional effect on reducing nocturnal urine volume. Multivariate logistic regression analysis showed that lower serum sodium levels (odds ratio [OR], 0.41, P=0.037) and the presence of urge incontinence (OR, 7.08, P=0.036) were predictors of a significant improvement of nocturia in response to 0.4 mg of tamsulosin. Conclusions: Dose escalation may yield a significant improvement of nocturia in>20% of patients, and may be especially helpful in patients with lower sodium levels and urge incontinence.
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참고문헌 (22)
참고문헌 신청
Choo MS / 2008 / Prevalence of nocturia in a Korean population aged 40 to 89 years / Neurourol Urodyn 27:60~64
Weiss JP / 2000 / Nocturia / J Urol 163:5~12
강동일 / 2010 / Short Term Effect and Safety of Antidiuretic Hormone in the Patients with Nocturia / International Neurourology Journal 14(4):227~231
Wang CJ / 2011 / Low dose oral desmopressin for nocturnal polyuria in patients with benign prostatic hyperplasia : a double-blind, placebo controlled, randomized study / J Urol 185:219~223
Park CH / 2004 / Efficacy of low-dose tamsulosin on lower urinary tract symptoms suggestive of benign prostatic hyperplasia : a nonblind multicentre korean study / Clin Drug Investig 24:41~47
Weiss JP / 2000 / Nocturia / J Urol 163:5~12
강동일 / 2010 / Short Term Effect and Safety of Antidiuretic Hormone in the Patients with Nocturia / International Neurourology Journal 14(4):227~231
Wang CJ / 2011 / Low dose oral desmopressin for nocturnal polyuria in patients with benign prostatic hyperplasia : a double-blind, placebo controlled, randomized study / J Urol 185:219~223
Park CH / 2004 / Efficacy of low-dose tamsulosin on lower urinary tract symptoms suggestive of benign prostatic hyperplasia : a nonblind multicentre korean study / Clin Drug Investig 24:41~47
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