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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 126 - 131 (6page)
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CD4+CD25+FoxP3+ regulatory T (Treg) cells play major roles in the maintenance of immune homeostasis. In this review, we comprehensivelydescribe the relationship between tumor necrosis factor (TNF) and Treg cells, focusing on the effects of TNF on Tregcells and on TNF-producing Treg cells. Contradictory results have been reported for the effect of TNF on the suppressive activityof Treg cells. In patients with rheumatoid arthritis, TNF has been shown to reduce the suppressive activity of Treg cells. Meanwhile,however, TNF has also been reported to maintain the suppressive activity of Treg cells via a TNFR2-mediated mechanism. In addition, Treg cells have been found to acquire the ability to produce TNF under inflammatory conditions, such as acute viralhepatitis. These TNF-producing Treg cells exhibit T helper 17-like features and hold significance in various human diseases.
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참고문헌 (60)
참고문헌 신청
Ehrenstein MR / 2004 / Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy / J Exp Med 200:277~285
Chen X / 2008 / Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells : applicability to tumor-infiltrating T regulatory cells / J Immunol 180:6467~6471
Chen X / 2010 / TNF-alpha : an activator of CD4+FoxP3+TNFR2+ regulatory T cells / Curr Dir Autoimmun 11:119~134
Pierini A / 2016 / TNF-α priming enhances CD4+FoxP3+ regulatory T-cell suppressive function in murine GVHD prevention and treatment / Blood 128:866~871
Nagar M / 2010 / TNF activates a NF-kappaB-regulated cellular program in human CD45RA-regulatory T cells that modulates their suppressive function / J Immunol 184:3570~3581
Chen X / 2008 / Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells : applicability to tumor-infiltrating T regulatory cells / J Immunol 180:6467~6471
Chen X / 2010 / TNF-alpha : an activator of CD4+FoxP3+TNFR2+ regulatory T cells / Curr Dir Autoimmun 11:119~134
Pierini A / 2016 / TNF-α priming enhances CD4+FoxP3+ regulatory T-cell suppressive function in murine GVHD prevention and treatment / Blood 128:866~871
Nagar M / 2010 / TNF activates a NF-kappaB-regulated cellular program in human CD45RA-regulatory T cells that modulates their suppressive function / J Immunol 184:3570~3581
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