지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 454 - 460 (7page)
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초록· 키워드
오류제보하기
Purpose: The present study investigated chest computed tomography (CT) patterns and lung histological features, as well as theconsistency between radiological and histological features among patients with microscopic polyangiitis (MPA), granulomatosiswith polyangiitis (GPA), and eosinophilic GPA (EGPA). Materials and Methods: The medical records of 74 antineutrophil cytoplasmic antibody-associated vasculitis (AAV) patients withradiological lung parenchymal lesions were reviewed along with the histological results for 28 of them. Chest CT patterns were dividedaccording 12 items mostly suggested by radiologists and histological features were divided according to necrotising granuloma,necrotising vasculitis, eosinophilic infiltration, and hemosiderin laden macrophages as defined by a pathologist. Results: The mean age was 57.1 years (22 men). The most common clinical manifestation other than lung manifestation was renalmanifestation (62.2%), and the most common chest CT pattern was lung involvement of vasculitis (35.1%). In MPA patients, the majorhistological features were hemosiderin-laden macrophages in the alveolar space and vasculitis. In GPA patients, the major histologicalfeatures were necrotizing vasculitis and necrotizing granuloma, while in EGPA patients, the major histological feature wasonly necrotising vasculitis. The consistency rate in GPA patients was the highest (100%), followed by that in MPA patients (66.7%)and EGPA patients (50.0%). Conclusion: When lung involvement of AAV is suspected on chest CT, lung biopsy should be recommended for the proper classificationof AAV, due to the discordance rate between radiological and histological findings in MPA and EGPA patients, but not GPApatients.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Jennette JC / 2013 / 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides / Arthritis Rheum 65:1~11
Mukhtyar C / 2009 / Modification and validation of the Birmingham Vasculitis Activity Score(version 3) / Ann Rheum Dis 68:1827~1832
Stone JH / 2001 / A disease-specific activity index for Wegener’s granulomatosis:modification of the Birmingham Vasculitis Activity Score. International Network for the Study of the Systemic Vasculitides (INSSYS) / Arthritis Rheum 44:912~920
Millet A / 2013 / Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group? / Ann Rheum Dis 72:1273~1279
Alba MA / 2017 / Interstital lung disease in ANCA vasculitis / Autoimmun Rev 16:722~729
Mukhtyar C / 2009 / Modification and validation of the Birmingham Vasculitis Activity Score(version 3) / Ann Rheum Dis 68:1827~1832
Stone JH / 2001 / A disease-specific activity index for Wegener’s granulomatosis:modification of the Birmingham Vasculitis Activity Score. International Network for the Study of the Systemic Vasculitides (INSSYS) / Arthritis Rheum 44:912~920
Millet A / 2013 / Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group? / Ann Rheum Dis 72:1273~1279
Alba MA / 2017 / Interstital lung disease in ANCA vasculitis / Autoimmun Rev 16:722~729
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