지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,174 - 1,180 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Bone markers can be useful for the diagnosis and treatment of skeletal diseases in children and adolescents. Owing tohigh skeletal growth velocity and rapid bone turnover, children and adolescents have higher bone marker levels than adults. Thus, a valid age- and sex-specific reference should be established for pediatric populations living in similar environments. Weaimed to assess the associations of procollagen type I N-terminal propeptide (P1NP) and osteocalcin with age and sex in a groupof healthy Korean children and adolescents. Materials and Methods: The participants (290 boys and 290 girls, age range 0–18 years) were Korean outpatients. Serum P1NPand osteocalcin levels were measured in control materials and patient samples by electrochemiluminescence immunoassay usingan automated Cobas e411 analyzer. Results: Significant age-dependent variations in bone marker levels were observed in both sexes (p<0.001). The highest P1NPlevels were observed during the first year of life; thereafter, levels decreased until puberty. There was no postnatal peak for osteocalcin;however, its levels remained higher than the adult reference range throughout childhood. Significant differences were observedbetween boys and girls (p<0.05), especially between the ages of 12 and 17 years. Cobas e411 results for P1NP showed satisfactoryprecision and linearity. Conclusion: We established reference data for P1NP and osteocalcin levels in healthy Korean children and adolescents, as thefirst and only study of these parameters in pre-adulthood in Korea. Cobas e411-quantified bone markers may be useful for determiningbone metabolism indices.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Jürimäe J / 2010 / Interpretation and application of bone turnover markers in children and adolescents / Curr Opin Pediatr 22:494~500
Barera G / 2004 / Longitudinal changes in bone metabolism and bone mineral content in children with celiac disease during consumption of a gluten-free diet / Am J Clin Nutr 79:148~154
Okabe R / 2001 / Clinical evaluation of the Elecsys beta-CrossLaps serum assay, a new assay for degradation products of type I collagen C-telopeptides / Clin Chem 47:1410~1414
Khadka B / 2018 / Correlates of biochemical markers of bone turnover among post-menopausal women / JNMA J Nepal Med Assoc 56:754~758
Szulc P / 2000 / Biochemical measurements of bone turnover in children and adolescents / Osteoporos Int 11:281~294
Barera G / 2004 / Longitudinal changes in bone metabolism and bone mineral content in children with celiac disease during consumption of a gluten-free diet / Am J Clin Nutr 79:148~154
Okabe R / 2001 / Clinical evaluation of the Elecsys beta-CrossLaps serum assay, a new assay for degradation products of type I collagen C-telopeptides / Clin Chem 47:1410~1414
Khadka B / 2018 / Correlates of biochemical markers of bone turnover among post-menopausal women / JNMA J Nepal Med Assoc 56:754~758
Szulc P / 2000 / Biochemical measurements of bone turnover in children and adolescents / Osteoporos Int 11:281~294
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