지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The isomeric intermediates, $3{\alpha}$and $3{\beta}-amino-5{\alpha}-cholestane required for the synthesis of N-nitrosoureas, N-(2-chloroethyl)-N-nitrosocarbamoyl-$3{\alpha}-amino-5{\alpha}$-cholestane (9), N-methyl-N-nitrosocarbamoyl-3${\alpha}-amino-5{\alpha}-cholestane$ (10), N-(2-chloroethyl)-N-nitrosocarbamoyl-$3{\beta}-amino-5{\alpha}-cholestane$: (7), and N-methyl-N-nitrosocarbamoyl-$3{\beta}-amino-5{\alpha}-cholestane$ (8) were obtained through the $LiAlH_{4}$ reduction of $5{\alpha}$-cholestan-3-one oxime, followed by the chromatographic separation: the assignment of the stereochemistry of both isomers were based on the shape and chemical shift of $C_{3}$-proton resonances on their NMR spectra and on the elution mobility on the TLC. The urea intermediates, N-(2-chloroethyl) carbamoyl-3.alpha.-amino-5.alpha.-cholestane (13), N-methylcarbamoyl-$3{\alpha}-amino-5{\alpha}-cholestane$ (14), N-(2-chloroethyl) carbamoyl-$3{\beta}-amino-5{\alpha}-cholestane (11) and N-methyl-$3{\beta}-amino-5{\alpha}$-cholestane (12) were prepared by the treatment of each isomers ($3{\alpha}$-amino-and $3{\beta}-amino-5{\alpha}$-cholestane) with alkyl isocyanates in anhydrous $CHCl_{3}$, and the corresponding nitrosoureas, 7-10 were obtained by the nitrosation of the ureas, 11-14, with AcOH (or HCOOH)/$NaNO_{2}$ in ice-cold condition. The inhibitory activity of the nitrosoureas, 7-10, and their intermediates, 12-14 towards the growth of L1210 murine leukemia cells, were examined. Among them, the compounds 9 and 10 exhibited high activity having $ED_{50}$ to be 5.5g/ml and 6.1g/ml, respectively.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
An Efficient Synthesis of Cyclic $\alpha$, $\alpha$-Disubstituted $\alpha$-Amino Acids
대한약학회 학술대회
2001 .01
-
Synthesis of Steroidal Nitrosoureas as Antitumor Activity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1986 .01
-
Possible target for G protein antagonist: Identification of specific amino acid residue responsible for the molecular interaction of G$\alpha$ 16 with chemoattractant C5a receptor.
한국응용약물학회 춘계학술발표논문집
2000 .01
-
N-(Alkyl-N'-nitrosocarbamoyl)-amino Acid Ester류의 合成 및 抗癌 作用 評價
약학회지
1984 .01
-
The constituents of taraxacum hallaisanensis roots
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
Microbial $9{\alpha}$-Hydroxylase:Epoxidation of 9(11)-dehydro-$17{\alpha}$-methyl-testosterone
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
New inhibitors of the NF-kB activation and NO production from Artemisia sylvatica
대한약학회 학술대회
2003 .01
-
Androstane과 Cholestane 유도체의 진통, 소염 및 항고지혈 효과
약학회지
2007 .01
-
New approach to the synthesis of $\alpha$-amino acids by CSI reaction with allyl ethers
대한약학회 학술대회
2000 .01
-
내독소에 의한 말초혈액 단핵구의 IL-1beta, IL-6, TNF-alpha와 TGF-beta 생성에 관한 연구
Tuberculosis and Respiratory Diseases
1998 .01
-
Stereoselective synthesis of novel 4′$\alpha$-C-methyl branched novel carbocyclic nucleosides
대한약학회 학술대회
2002 .01
-
팔방산호충류에서 분리한 해양 스테롤 화합물의 혈소판 응집 억제작용
약학회지
1997 .01
-
A Novel Synthetic Methods for $\alpha$-Amino Acids from Allyl Ethers via N-Allylcarbamates
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
-
T 세포 하이브리도마에 의한 ${\alpha}2-Macroglobulin$의 생산
약학회지
1994 .01
-
한국 전통 간장의 숙성중 관능적 품질에 미치는 성분의 변화-아미노산성질소,아미노산 및 색도르 중심으로
한국환경보건학회지
2004 .01
-
Electrochemically Hydroxyapatite Precipitated Nanotube Surface on Alpha/Beta Ti Phase
대한치과재료학회 학술대회
2013 .04
-
Incremental Expression of 14-3-3 Protein Beta/Alpha in Urine Correlates with Advanced Stage and Poor Survival in Patients with Clear Cell Renal Cell Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Colchicine Inhibits Integrin ${\alpha}_5{\beta}_1$ Gene Expression during PMA induced dDfferentiation of U937 Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1995 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0