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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 1993.1
- 수록면
- 73 - 73 (1page)
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As part of a research program to develope 3rd generation anti tumor platinum complexes, a series of platinum complexes which have 4, 5-bis-(aminomethyl)- 1, 3-dioxolane derivatives as bidenate amine ligands, represented by the general structual formula was prepared. The R$_1$ and/or R$_2$ substituents in this series of platinum complexes can be hydrogen. alkyl, of jointly formed cyclohexane. Two Xs can be a bidenate leaving ligand such as 1, 1-cyclobutanedicarboxylate, malonate, dimethylmalonate, ethylmalonate, glycolate, L-lactate, or N-methyliminodiacetate. From based on the pharmacological and toxicological studies, we have chosen SKI 2053R, cis-malonato[(4R, 5R)-4, 5-bis(aminomethyl)-2-isopropyl-1, 3-dioxolane] platinum(II) complex (NSC D644591) as a candidate for clinical evaluation. The antitumor activity of a new anti tumor platinum complex, cis-malonato [(4R, 5R)-4, 5-bis(aminomethyl)-2-isopropyl-1, 3-dioxolane] platinum(II) (SKI 2053R, NSC D644591), was compared with those of cisplatin and carboplatin using murine tumors. We evaluated three platinum complexes against L1210/CPR, a subline of L1210 leukemia resistant to cisplatin for their abilities to overcome tumor resistance to cisplatin. The in vitro cytotoxicity of SKI 2053R to L1210 cell line was 2.5-fold less potent thann that of cisplatin, and was 10-fold more cytotoxic than that of carboplatin. SKI 2053R retained similar cytotoxic effect and anti tumor activity to L1210/CPR cell line, like the cytotoxicity of SKI 2053R to L1210 cell line, while either cisplatin or carboplatin had not property to overcome the acquired cisplatin-resistance. SKI 2053R exhibited greater or comparable antitumor activity than cisplatin or carboplatin in murine tumor models.
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랫드와 마우스에서 cis-Malonato [ ( 4R , 5R ) - 4 , 5 - bis ( aminomethyl ) - 2 - Isopropyl - 1 , 3 - Dioxolane ] Platinum ( II ) ( SKI 2053R ) 의 급성독성에 관한 연구 ( Acute Toxicity of cis-Malonato [ ( 4R , 5R ) - 4 , 5 - bis ( aminomethyl ) - 2 - Isopropyl - 1 , 3 - Dioxolane ] Platinum ( II ) ( SKI 2053R ) In Rats and Mice )
한국독성학회지
1992 .12
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랫드와 마우스에서 cis-Malonato [ ( 4R , 5R ) - 4 , 5 - bis ( aminomethyl ) - 2 - Isopropyl - 1 , 3 - Dioxolane ] Platinum ( II ) ( SKI 2053R ) 의 아급성독성시험에 관한 연구 ( Subacute Toxicity of cis-Malonato [ ( 4R , 5R ) - 4 , 5 - bis ( aminomethyl ) - 2 - Isopropyl - 1 , 3 - Dioxolane ] Platinum ( II ) ( SKI 2053R ) In Rats )
한국독성학회지
1992 .12
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기니픽 및 마우스에서 cis-Malonato [ ( 4R , 5R ) - 4 , 5 - bis ( aminomethyl ) - 2 - Isopropyl - 1 , 3 - Dioxolane ] Platinum ( II ) ( SKI 2053R ) 의 항원성시험 ( Antigenicity Test of cis-Malonato [ ( 4R , 5R ) - 4 , 5 - bis ( aminomethyl ) - 2 - Isopropyl - 1 , 3 - Dioxolane ] Platinum ( II ) ( SKI 2053R ) In Guinea Pigs and Mice )
한국독성학회지
1992 .12
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Beagle Dog에서 cis-Malonato [ ( 4R , 5R ) - 4 , 5 - bis ( aminomethyl ) - 2 - Isopropyl - 1 , 3 - Dioxolane ] Platinum ( II ) ( SKI 2053R ) 의 아급성독성시험에 관한 연구 ( Subacute Toxicity of cis-Malonato [ ( 4R , 5R ) - 4 , 5 - bis ( aminomethyl ) - 2 - Isopropyl - 1 , 3 - Dioxolane ] Platinum ( II ) ( SKI 2053R ) In Beagle Dogs )
한국독성학회지
1992 .12
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제 3세대 백금착체 항암제 신약개발 2. Antitumor activity and ex vivo pharmacodynamics of SKI 2053R
한국응용약물학회 신약개발 연구발표회
1993 .01
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새로운 백금착물 항암제 SKI 2053R의 토끼 최기형성시험
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1999 .01
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In vitro Antitumor Activity and Nephrotoxicity of Pt(II) Complexes Containing Diaminocyclohexane
대한약학회 학술대회
2002 .01
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A novel cis/trans-diaminocyclohexane platinum coordination complexes possessing in vitro and in vivo antitumor activity
한국응용약물학회 춘계학술발표논문집
1997 .01
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In vitro antitumor activity and nephrotoxicity of a new platinum(II) complex on cancer cell-lines and normal kidney cells
대한약학회 학술대회
2001 .01
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In Vitro Cytotoxic Activities of Novel Platinum(II) Complex on Gastric Cancer Cell-Lines and Normal Kidney Cells
대한약학회 학술대회
2001 .01
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Cisplatin의 신장독성에 관한 연구 2. Cisplatin의 신장근위세뇨관 glucose 이동에 미치는 영향과 몇 가지 약물들의 독성경감효과 ( Studies on the Cisplatin Nephrotoxicity 2. Effects of cisplatin on the renal proximal tubular glucose transport and alleviating effects of some drugs on the renal toxicity of cisplatin )
한국환경성돌연변이·발암원학회지
1994 .03
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신규 백금착물 항암제 KBP31705-C127, KBP30603-901의 Cisplatin 및 Carboplatin과의 약동력학적 동태 비교
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1996 .01
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Lethal Effects of Radiation and Platinum Analogues on Multicellular Spheroids of HeLa Cells
Radiation oncology journal : ROJ
1989 .01
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상피성 난소암 환자에서 Platinum 중심 공고항암요법 (Consolidation Therapy)의 유효성 및 안전성에 관한 예비연구
Obstetrics & Gynecology Science
2004 .01
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Survival Outcomes of Recurrent Epithelial Ovarian Cancer: Experience from a Thailand Northern Tertiary Care Center
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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Selective Cytotoxicity of Novel Platinum(II) Complexes on Gastric Cancer Cell-Lines and Normal Kidney Cells
대한약학회 학술대회
2002 .01
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A novel cis/trans-diaminocyclohexane platinum coordination complexes possessing in vitro and in vivo antitumor activity
한국응용약물학회 춘계학술발표논문집
1997 .01
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1,3-비스페닐치오 프로판을 배위자로 한 백금 (II)착체의 선택적 세포독성
약학회지
1999 .01
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Cis-Platinum의 이중독증에 관한 임상적 고찰
대한기관식도과학회 학술대회
1982 .01
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Comparative bioavailability of novel antitumor platinum (IV) complexes, K101, K102, K103, and K104 in rats
대한약학회 학술대회
2002 .01
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