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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 저널정보
- 대한약학회 대한약학회 학술대회 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
- 발행연도
- 2003.1
- 수록면
- 1,732 - 1,732 (1page)
이용수
이 논문의 연구 히스토리 (2)
2003
N-4-Substituted-benzyl-N'-tert-butylbenzyl Thioureas as Vanilloid Receptor Ligands: Investigation on the Role of Methanesulfonamido group in Antagonistic Activity
Pa
,
k
,
Hyeung-Geun
외 32명
대한약학회 학술대회
2003.01
학술대회자료
Synthesis of N,N',N"-Trisubstituted Thiourea Derivatives and their Antagonistic Effect on the Vanilloid Receptor
Pa
,
k
,
Hyeung-Geun
외 17명
대한약학회 학술대회
2003.01
학술대회자료
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초록· 키워드
오류제보하기
Vanilloid receptor I (VR1) is a nonselective cation ion channel placed in the plasma membrane of peripheral sensory neurons that is potential target for analgesia A series of N-4-substituted-benzyl-N'-tert-butylbenzyl thioureas were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor in rat DRG. Their structure-activity relationship in reveals that not only the two oxygens and amide hydrogen of sulfonamido group but also the optimal size of methyl in methanesulfonamido group play an integral role for the antagonistic activity on vanilloid receptor.
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등록된 정보가 없습니다.
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