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논문 기본 정보

자료유형
학술저널
저자정보
심규원 (연세대학교 의과대학 신경외과학교실, 뇌연구소) 장종희 (연세대학교 의과대학 신경외과학교실, 뇌연구소) 최재영 (연세대학교 의과대학 신경외과학교실, 뇌연구소) 장진우 (연세대학교 의과대학 신경외과학교실, 뇌연구소) 박용구 (연세대학교 의과대학 신경외과학교실, 뇌연구소) 정상섭 (연세대학교 의과대학 신경외과학교실, 뇌연구소)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제30권 제11호
발행연도
2001.1
수록면
1,263 - 1,270 (8page)

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Objective : To analyze the radiosurgical results of intracranial meningiomas after Gamma Knife radiosurgery (GKS) and to assess the possible factors related to the outcome and complications in treating meningiomas. Patients and Methods : We retrospectively reviewed the clinical and radiological data in 179 patients(194 lesions) treated with GKS for intracranial meningiomas between May 1992 and October 2000. Radiosurgical responses were categorized as shrinkage, stasis and enlargement, and we defined the shrunken and static group as a radio-logical control. A Cox proportional hazards model was used to evaluate the correlation between the radiosurgical outcomes and various factors such as location and size of tumor, age and gender of patients, relation to venous sinus, pre-GKS degree of edema, treatment modality, radiosurgical parameters, and pathologic findings. Results : Patients were grouped into skull base meningiomas(57.7%), non-skull base tumor including convexity, parasagittal, and falx meningiomas(37.1%), and others(5.2%) according to the location of tumors. The mean maximum dose and the margin dose of tumor was 30.0Gy(19-45Gy) and 15.1Gy(9.5-24.5Gy), respectively. The mean volume of the tumors was 9.4cc(0.003-45.0cc). The radiologic control rate was 97.1%. The radiation induced imaging change with or without neurologic deficit was the most common complication(23.6%). There were seen mostly in convexity, parasagittal, and falx meningiomas which were deeply embedded in cortex. Conclusion : GKS for intracranial meningioma seems to be safe and effective treatments. However, GKS should be considered very cautiously in non-skull base tumor such as convexity, parasagittal, or falx meningiomas with regards to patient's age and general condition, size and location of tumor, pattern of embedding into cortex, presenting symptoms and patient's preference.

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