지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The pharmacotherapy of schizophrenia exhibits wide inter-individual variabilities in clinical efficacy and adverse effects. Recently, human genetic diversity has been known as one of the essential factors to the variation in human drug response. This suggests that drug therapy should be tailored to the genetic characteristics of the individual. Pharmacogenetics is the field of investigation that attempts to elucidate genetic basis of an individual's responses to pharmacotherapy, considering drug effects divided into two categories as pharmacokinetics and pharmacodynamics. The emerging field of pharmacogenomics, which focuses on genetic determinants of drug response at the level of the entire human genome, is important for development and prescription of safer and more effective individually tailored drugs and will aid in understanding how genetics influence drug response. In schizophrenia, pharmacogenetic studies have shown the role of genetic variants of the cytochrome P450 enzymes such as CYP2D6, CYP2C19, and CYP2A1 in the metabolism of antipsychotic drugs. At the level of drug targets, variants of the dopamine $D_2$, $D_3$ and $D_4$, and 5-$HT_{2A}$ and 5-$HT_{2C}$ receptors have been examined. The pharmacogenetic studies in schizophrenia presently shows controversial findings which may be related to the multiple involvement of genes with relatively small effects and to the lack of standardized phenotypes. For further development in the pharmacogenomics of schizophrenia, there would be required the extensive outcome measures and definitions, and the powerful new tools of genomics, proteomics and so on.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Pharmacogenomics in Relation to Tailor-made Drugs
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2006 .01
-
PHARMACOGENOMICS IN RELATION TO TAILOR-MADE DRUGS -INTRODUCTION-
한국응용약물학회 추계학술발표논문집
2006 .01
-
Drug Development in the age of pharmacogenomics: Issues facing Japan for genomics based drug development
한국응용약물학회 추계학술발표논문집
2005 .01
-
약물대사효소의 유전적 다형성 및 임상적 응용
한국임상약학회지
2006 .01
-
Introduction to Pharmacogenomics in New Drug Development
한국응용약물학회 추계학술발표논문집
2005 .01
-
The Cytochrome P450 Catalyzed Drug Metabolism in Drug Development: Pharmacogenetics and Drug Interactions
대한약학회 학술대회
2005 .01
-
Genetics of Treatment Outcomes in Major Depressive Disorder: Present and Future
Clinical Psychopharmacology and Neuroscience
2020 .01
-
우울증의 약물유전체학
생물정신의학
2001 .01
-
Pharmacogenomics of drug disposition: integrated understanding of gene-environmental interaction
한국응용약물학회 추계학술발표논문집
2005 .01
-
Significance of Pharmacogenetics in Drug Therapy
대한임상약리학회 학술대회
1995 .01
-
Modeling the drug response
대한임상약리학회 학술대회
1995 .01
-
Pharmacogenetics and Depression: A Critical Perspective
PSYCHIATRY INVESTIGATION
2019 .01
-
Pharmacogenomic Association Study between Genetic Polymorphic Variations of MDR-1 and CYP3A5 and Efficacy and Adverse Drug Reactions of Calcinuerin Inhibitors
한국응용약물학회 추계학술발표논문집
2006 .01
-
뇌혈관질환의 항혈전제 치료에 있어서 약물유전학
대한뇌졸중학회지
2010 .01
-
Pharmacogenetics of CNS drugs
대한임상약리학회 심포지움
2002 .01
-
천식 약물유전체 연구에서 시스템 생물학 접근
Allergy Asthma & Respiratory Diseases
2014 .01
-
CANCER PHARMACOGENOMICS
한국응용약물학회 추계학술발표논문집
2005 .01
-
The Pharmacogenetics of Symptom Response to Antipsychotic Drugs
PSYCHIATRY INVESTIGATION
2012 .01
-
약물상호작용의 원리와 의의
생물정신의학
2000 .01
-
항우울제와 연관약물의 약물상호작용
생물정신의학
2000 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0