지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1998.1
- 수록면
- 471 - 476 (6page)
이용수
초록· 키워드
오류제보하기
The G protein-activated inwardly rectifying $K^＋$ channel (GIRK1) was coex-pressed in Xenopus oocytes along with the $5-HT_{1A}$ receptor, a 7-helix receptor known to be coupled to $K^＋$ channels in many neural tissues. Thus, the activation of the $5-HT_{1A}$ receptor by its agonist leads to the opening of GIRK1. The GIRK1 current was measured using the two electrode voltage clamp technique with bath application of 5-HT in the presence of various external potassium concentrations $[K^＋]_0$. GIRK1 showed a strong inward rectification since only hyperpolarizing voltages evoked inward currents. $K^{+}$ was the major ion carrier as evidenced by about 44㎷ voltage shift corresponding to a 10-fold external 〔$K^＋$〕 change. 5-HT induced a concentration-dependent inward $K^＋$ current ($EC_{50}{\equation omitted}10.7nM$) which was blocked by $Ba^{2＋}$. Pertussis toxin (PTX) pre-treatment reduced the $K^＋$ current by as much as about 70%, suggesting that PTX-sensitive G protein ($G_i or G_o$ type) are involved in the $5-HT_{1A}$ receptor-GIRK1 coupling in Xenopus oocytes.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cloning and Characterization of Partial Maternal mRNA Genes in Xenopus Oocytes.
한국동물학회 학술대회
1995 .01
-
EXPRESSION PATTERN OF XENOPUS HOX-3.1 GENE TRANSCRIPTS DURING EMBRYOGENESIS IN XENOPUS LAEVIS
한국동물학회 학술대회
1995 .01
-
Utilization of a Storage Protein in the Embryonic Development of Drosophila and Xenopus
Korean journal of biological sciences
2001 .01
-
The Binding of Progesterone to the Plasma Membrane of Xenopus Oocytes: Characteristics of Binding and Hormonal and Developmental Control
한국동물학회 학술대회
1999 .01
-
Cloning of Xenopus laevis TRPV2 by Gene Prediction
Genomics & informatics
2005 .01
-
Viualization of Progesterone Binding to Plasma Membrane of Xenopus Oocytes
Korean journal of biological sciences
2001 .01
-
Characterization of a novel survivin-like gene expression in Xenopus laevis
한국동물학회 학술대회
2001 .01
-
Block of HERG Channels Expressed in Xenopus oocytes by External $Ca^{2+}$
한국생물물리학회 학술발표회
1997 .01
-
The Study on the Expression Pattern and Function of c-Ha-ras in Xenopus laevis
한국동물학회 학술대회
1994 .01
-
The Polycomb Group Protein Pc12 Interacts with YY1, and Both Proteins Regulate Neural Tissue Development in Xenopus Embryos
한국동물학회 학술대회
2003 .01
-
Phytosphingosine-1-phosphate stimulates chemotacticmigration of L2071 mouse fibroblasts via pertussistoxin-sensitive G-proteins
Experimental and Molecular Medicine
2007 .01
-
A pertussis toxin sensitive G-protein-independent pathway is involved in serum amyloid A-induced formyl peptide receptor 2-mediated CCL2 production
Experimental and Molecular Medicine
2010 .01
-
Ultrastructure of the Follicular Oocyte Surface in Rana dybowskii
Korean journal of biological sciences
2001 .01
-
Toxicities of Difenoconazole on the Development of Xenopus laevis
한국생명과학회 심포지움
2008 .10
-
Toxicities of Isoprothiolane on the Development of Xenopus laevis
한국생명과학회 심포지움
2008 .10
-
Cloning of Homeobox-containing gene and its expression study in the early development of Xenopus laevis
한국동물학회 학술대회
1996 .01
-
종양억제유전자 p53 결손 인체간암세포에서 Pectenotoxin-2에 의한 Apoptosis 유도
생명과학회지
2007 .10
-
Study on the Organogenesis of Lymph Heart in the Early Stage Xenopus laevis
한국동물학회 학술대회
1995 .01
-
Control of organogenesis in undifferentiated and cultured cells in Xenopus laevis
한국동물학회 학술대회
1999 .01
-
Effects of benomyl on animal cap explants and on whole-mount in Xenopus early embryo
한국동물학회 학술대회
2001 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0