지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Anticoagulant activities were tested for the fifteen kinds of medicinal plants by measuring activated partial thromboplastin time (aPTT). Of them five kinds or species (Artemisia princeps, Sanguisorba officinalis, Artemisia apiacea, Eclipa alba, Schizonepeta tenuifolia) were selected and fractionated for the preparation of acidic polysaccharides. They were extracted with water by refluxing and the extracts were precipitated with ethanol. The precipitates were separated based on charge using a DEAE-Sephadex. The low salt and high salt fractions were sulfated with anhydrous pyridine and chlorosulfonic acid complex. In vitro anticoagulant activities of sulfated polysaccharides were tested by measuring aPTT, prothrombin time (PT), and factor Xa clotting time using normal human plasma. No relationship was found between the amount of uronic acids and anticoagulant activities, but the sulfated ones show the increase of activities. In vivo anticoagulant properties of the sulfated polysaccharide from Artemisia apiacea were also tested by the intraveneous administration of three different doses (3,5 and 10 mg/kg) to rats. APTT and PT were increased significantly and the action of factor Xa and thrombin mediated through antithrombin III were inhibited slightly.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Immunomodulating and Anticoagulant Activity of Glycosaminoglycans Derived from Porcine Testis
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
Identification of Anticoagulant Components in Korean Red Ginseng
Journal of Ginseng Research
2010 .12
-
The Anticoagulant Fraction from the Leaves of Diospyros Kaki L. Has an Antithrombotic Activity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Immuno-stimulating activities of 4 years and 6 years red ginseng acidic polysaccharide
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Alteration of Regenerative Response of Sulfated Polysaccharide Purified from Ecklonia Cava in Small Intestinal Stem Cells After Radiation Injury
한국실험동물학회 학술발표대회 논문집
2014 .02
-
Purification and Characterization of Anticoagulant Protein from the Tabanus, Tabanus bivittatus
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Anticoagulant Activity of Acharan Sulfate In Vivo
대한약학회 학술대회
2003 .01
-
anticoagulant and thrombolytic therapy
대한외과학회 학술대회 초록집
2001 .11
-
Anticoagulant 1,2,3,4,6-Pentagalloyl-$\beta$-D-Glucopyranose Isolated from Geranium (Pelargonium inquinans Ait)
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Study on Atitumor and Immunomodulating Acivities of Polysaccharide Fractions from Panax ginseng : Comparison of effects of neutral and acidic polysaccharide fraction
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1990 .01
-
Anticoagulant activity of ethylacetate fraction of Korean Red Ginseng and its active components
고려인삼학회 학술대회
2008 .12
-
Non-Vitamin K Oral Anticoagulants in Stroke Patients: Practical Issues
대한뇌졸중학회지
2017 .01
-
자가제조 동결건조혈장을 이용한 동종 기기에 대한 PT와 aPTT 외부정도관리
Annals of Laboratory Medicine
2004 .01
-
Antitumor and Immunomodulating Activities of the Polysaccharide Fractions from Artemisia selengensis and Artemisia iwayomogi
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1994 .01
-
Influence of Blood Lipids on Global Coagulation Test Results
Annals of Laboratory Medicine
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0