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논문 기본 정보

자료유형
학술저널
저자정보
Yang, Young-Sun (Department of Physiology, Gyeongsang National University College of Medicine) Park, Young-Geun (Department of Physiology, Gyeongsang National University College of Medicine) Cho, Soo-Wan (Department of Physiology, Gyeongsang National University College of Medicine) Cheong, Seung-Jin (Department of Physiology, Gyeongsang National University College of Medicine) Haan, Jae-Hee (Department of Physiology, Gyeongsang National University College of Medicine) Park, Choon-Ok (Department of Physiology, Gyeongsang National University College of Medicine) Hong, Seong-Geun (Department of Physiology, Gyeongsang National University College of Medicine)
저널정보
대한생리학회 대한생리학회지 대한생리학회지 제27권 제1호
발행연도
1993.1
수록면
107 - 114 (8page)

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Most of voltage operated $Ca^{2+}$ channels can be divided into three types (T-, N-, and L-type), according to the electrical and pharmacological properties. Their distribution is closely related to cell specific functions. Properties of the voltage activated $Ca^{2+}$ current in mouse eggs were examined to classify channel types and to deduce the function by using whole cell voltage clamp technique. $Ca^{2+}$ currents appeared below -40 mV and reached a maximum at -15 mV (half maximum was -31 mV), then decayed rapidly (inactivation time constant ${\tau}=28.2{\pm}9.59$ ms at -10 mV within 50 ms after the onset of step depolarization. Activation and inactivation of the $Ca^{2+}$ channel was steeply dependent on voltage, in a relatively low range of $-70\;mV{\sim}-10 mV,$ half maximum of activation was -31 mV and that of inactivation was -39 mV, respectively. This current was not decreased significantly by nifedipine, a specific dihydropyridine $Ca^{2+}$ channel blocker in the range of $1\;{\mu}M\;to\;100{\mu}M.$ The inhibitory effect of $Ni^{2+}\;on\;Ca^{2+}$ current was greater than that of $Cd^{2+}.$ The conductance of $Ba^{2+}$ through the channel was equal to or lower than that of $Ca^{2+}$ These results implied that $Ca^{2+}$ current activated at a lower voltage in the mouse egg is carried via a $Ca^{2+}$ channel with similar properties that of the T-type channel.

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