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논문 기본 정보

자료유형
학술저널
저자정보
Choi Su-La (Clinical Biochemistry Lab, Department of Pharmacy, College of Pharmacy, Chungnam National University, Research Center for Transgenic Cloned Pigs, Chungnam National University) Choi Yun-Sil (Clinical Biochemistry Lab, Department of Pharmacy, College of Pharmacy, Chungnam National University, Research Center for Transgenic Cloned Pigs, Chungnam National University) Kim Young-Kwan (Clinical Biochemistry Lab, Department of Pharmacy, College of Pharmacy, Chungnam National University, Research Center for Transgenic Cloned Pigs, Chungnam National University) Sung Nack-Do (Division of Applied Biology & Chemistry, College of Agriculture & Life Sciences, Chungnam National University, Research Center for Transgenic Cloned Pigs, Chungnam National Univer) Kho Chang-Won (Division of Life Sciences, Korea Research Institute of Bioscience and Biotechnology, Research Center for Transgenic Cloned Pigs, Chungnam National University) Park Byong-Chul (Division of Life Sciences, Korea Research Institute of Bioscience and Biotechnology) Kim Eun-Mi (Division of Life Sciences, Korea Rese) Lee Jung-Hyung Kim Kyung-Mee Kim Min-Yung Myung Pyung-Keun
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제29권 제3호
발행연도
2006.1
수록면
224 - 234 (11page)

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We employed human SK-MEL-28 cells as a model system to identify cellular proteins that accompany N-(4-methyl)phenyl-O-(4-methoxy)phenyl-thionocarbamate (MMTC)-induced apoptosis based on a proteomic approach. Cell viability tests revealed that SK-MEL-28 skin cancer cells underwent more cell death than normal HaCaT cells in a dose-dependent manner after treatment with MMTC. Two-dimensional electrophoresis in conjunction with matrixassisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry analysis or computer matching with a protein database further revealed that the MMTC-induced apoptosis is accompanied by increased levels of caspase-1, checkpoint suppressor-1, caspase-4, NF-kB inhibitor, AP-2, c-Jun-N-terminal kinase, melanoma inhibitor, granzyme K, G1/S specific cyclin D3, cystein rich protein, Ras-related protein Rab-37 or Ras-related protein Rab-13, and reduced levels of EMS (oncogene), ATP synthase, tyrosine-phosphatase, Cdc25c, 14-3-3 protein or specific structure of nuclear receptor. The migration suppressing effect of MMTC on SK-MEL-28 cell was tested. MMTC suppressed the metastasis of SK-MEL-8 cells. It was also identified that MMTC had little angiogenic effect because it did not suppress the proliferation of HUVEC cell line. These results suggest that MMTC is a novel chemotherapeutic and metastatic agents against the SK-MEL-28 human melanoma cell line.

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