지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Cigarette smoking is known to suppress both 1-methy14-phenyl-155,Ltetrahydropy-ridine (MPTP)-induced parkinsonism and idiopathic Parkinson's disease (PD). However, the precise mechanism underlying its protective action against PD is not clearly elucidated yet. In order to find possible clue on the mechanism of protective action of smoking, we investigated the inhibitory effect of cigarette smoke components on rat brain mitochondria1 monoamine oxidase B (MAO-B), responsible enzyme for the activation of MPTP to its toxic metabolitesr and identified the components having an inhibitory potency on this enzyme from cigarette smoke. Total 31 eligible constituents including nicotine were selected from cigarette smoke condensates via solvents partitioning and silica gel chromatographic separation, and inhibitory potencies of 19 components on MAO-B were determined. Hydroquinone and methylcatechol, the phenolic components, showed the strongest inhibitory potencies on MAO-B activity in the components tested. 3,4-Dihydroxybenzylamino, myosmine and indole in basic fracton, eugenol in phenolic fraction, and farnesol in neutral fraction also inhibited the enzyme activity dose-dependently. Among tobacco alkaloids tested only myosmine was effective for the inhibition of this enzyme. These results suggest that the decrease in MAO-B activity by such components derived from cigarette smoke seems to be related to the suppression of MPTP-induced neurotoxicity and to the less incidence of Parkinson's disease in smokers than in nonsmokers.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The effect of some additives on the formation of cigarette smoke
한국연초학회 학술발표회
2005 .01
-
CIGARETTE PAPER : A useful tool for the design of a cigarette
한국연초학회 학술발표회
2002 .01
-
담배 Mainstream Smoke중 Semi-volatile 화합물 연구
한국연초학회지
1998 .01
-
담배연기중 일산화질소의 신속분석
한국연초학회지
1993 .01
-
담배주류연의 세포독성에 대한 담배필터의 영향
한국연초학회지
2005 .01
-
Determination of Cadmium Transfer Rate from the Tobacco to Cigarette Smoke
한국연초학회지
2010 .01
-
EFFECT OF CIGARETTE PAPER ON CIGARETTEAPPEARANCE BURN RATE AND SIDESTREAM SMOKE
한국연초학회 학술발표회
2000 .01
-
제품담배 연기성분 분포 특성 조사 및 물리적 특성과의 관련성 구명
한국연초학회지
2001 .01
-
저부류연 궐련지의 이화학적 특성과 주 $\cdot$ 부류연 연기성분 이행특성
한국연초학회지
2005 .01
-
The relationship between smoke yields and tipping materials of the cigarette under restricted conditions
한국연초학회 학술발표회
1998 .01
-
궐련지의 섬유종류가 담배 연기성분에 미치는 영향
한국연초학회지
1999 .01
-
Basic Mechanism of Cigarette Smoldering and Smoke Formation
한국연초학회 학술발표회
2002 .01
-
Effect of Cigarette Smoke Exposure Against Oxidative Damage in Scrapie-infected Mice
한국연초학회지
2009 .01
-
Structure-Activity Relationship of Dietary Flavonoids for Inhibitory Activity of Mouse Brain Monoamine Oxidase (MAO) in vitro
Food Science and Biotechnology
2000 .10
-
What's Hoffmann's List Compounds in Cigarette Smoke!
한국연초학회 학술발표회
2004 .01
-
궐련지 기공도가 담배연기 희석에 미치는 영향
한국연초학회지
1985 .01
-
Phenolics with Inhibitory Activity on Mouse Brain Monoamine Oxidase (MAO) from Whole Parts of Artemisia vulgaris L (Mugwort)
Food Science and Biotechnology
2000 .06
-
Study of the Semi-volatile Components in Cigarette Mainstream Smoke
한국연초학회 학술발표회
1998 .01
-
Screening for Plants to Suppress Oxidation of Pulmonary Microsome Exposed to Cigarette Smoke
Food Science and Biotechnology
1999 .08
-
엽배합 특성에 따른 담배 연기성분과 관능특성과의 상관관계 구명
한국연초학회지
2003 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0