지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제13권 제2호
- 발행연도
- 2005.1
- 수록면
- 113 - 117 (5page)
이용수
초록· 키워드
오류제보하기
Organosulfur compounds have been shown to exert an anti-cancer activity. In an attempt to develop novel chemopreventive and anti-cancer agents for liver cancer, we synthesized allylthiopyridazine derivatives. We have previously shown that allylthiopyridazine derivatives exert inhibitory effects on proliferation, invasion and migration of SK-Hep-1 hepatocarcinoma cells in vitro. The in vivo anti-tumor effect of 3-methvl-6-allylthiopy-ridazine, named as K6, was also reported. In this study, we further investigated the preclinical anti-cancer efficacy of K6 for hepatocarcinoma using nude mice xenografted with Hep-G2 hepatocellular carcinoma cells. K6(20-100 mg/kg, orally administered everyday for 30 days) markedly decreased the tumor volume of Hep-G2 cell-transplanted nude mice as evidenced by ultrasonographic and plethysmogranhic analyses. The inhibitory effect on tumor volume was lower than that exerted by doxorubicin (2 mg/kg), intravenously injected) which was used as a positive control. This study shows that K6 efficiently suppresses xenograft tumor growth, revealing K6 as apotential anti-cancer agent for suppressing in vivo progression of liver cancer. Given that hepatocarcinoma is among the most prevalent and lethal malignancies and there is no effective treatment to date, our study may contribute to the potential drug development for liver cancer.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Chemopreventive Allylthiopyridazines, K compounds, Inhibit Invasion, Migration and Angiogenesis in SK-Hep-1 Hepatocarcinoma Cells Possibly via MMP-2 Downregulation
대한약학회 학술대회
2003 .01
-
Antitumor Activity of K6, an Allylthiopyridazine Derivative, in Hep-G2 Cells-transplanted Nude Mice
Laboratory Animal Research
2004 .03
-
Animal model of cancer : A nude mouse xenograft
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Inhibitory effect of red ginseng preparations on the growth of tumors xenografted in nude mice
한국실험동물학회 학술발표대회 논문집
2008 .11
-
Synthesis of 3-Alkylthio-6-Allylthiopyridazine Derivatives and Their Antihepatocarcinoma Activity
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
4,5-치환 3-alkoxy-6-allylthiopyridazine 유도체 합성
약학회지
2002 .01
-
Mouse models in cancer research
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Chemopreventive potential of the synthetic allylthiopyridazine derivatives on hepatocellular carcinoma cells
대한약학회 학술대회
2000 .01
-
Human Tumor Xenograft Models for Preclinical Assessment of Anticancer Drug Development
Toxicological Research
2014 .03
-
알릴티오피리다진 유도체 합성 및 UV-C조사에 대한 방어효과
약학회지
2000 .01
-
Preclinical Study of Novel Curcumin Analogue SSC-5 Using Orthotopic Tumor Xenograft Model for Esophageal Squamous Cell Carcinoma
Cancer Research and Treatment
2018 .01
-
Retrospective analysis of tumor xenograft models for human cancer therapeutics
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Viscum Album Var Hot Water Extract Mediates Anti-cancer Effects through G1 Phase Cell Cycle Arrest in SK-Hep1 Human Hepatocarcinoma cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
3-메톡시-6-알릴치오피리다진의 사람 췌장암 세포 사멸작용
약학회지
2005 .01
-
NCI-H460 폐암 유발 누드마우스 모형을 이용한 난담반의 항암 효과 연구
동의생리병리학회지
2010 .01
-
Mouse models for cancer research
한국실험동물학회 학술발표대회 논문집
2020 .02
-
3-Allylthio-6-heterocyclylalkylaminopyridazine 유도체 합성 및 SK-Hep-1 인간간암세포에 대한 항암효과
약학회지
2005 .01
-
Protective effects of synthetic of 3-Alkoxy-6-allylthiopyridazine against aflatoxin $B_1$- induced hepatotoxicity
대한약학회 학술대회
2003 .01
-
Inhibition of Cell Growth and Induction of Apoptosis by the Black Ginseng Extract in Human Hepatocellular Carcinoma Xenograft in Nude Mice
한국실험동물학회 학술발표대회 논문집
2009 .08
-
Xenograft Models of Human Gastric Cancer in Nude Mice : Heterotopic Xenograft Model & Orthotopic Xenograft Model
한국실험동물학회 학술발표대회 논문집
2012 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0