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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제24권 제2호
- 발행연도
- 2001.1
- 수록면
- 119 - 125 (7page)
이용수
초록· 키워드
오류제보하기
We have reported that kalopanaxsaponin A (KPS-A) Isolated from Kalopanax pictus have anti-rheumatoidal activity in the rat treated with Freunds complete adjuvant (FCA) reagent. In addition, it has been also reported that KPS-A is a potent antioxidant in the rheumatoidal rat. This research was undertaken to examine whether the saponins of KPS-A and -1 could adjust the abnormal lipid metabolisms and hematological changes in immunological diseases. KPS-A significantly inhibited the increases in both triglycerides and total proteins in addition to the decrease in total cholesterol induced by FCA reagent treatment. KPS-A treatment decreased the number of leucocytes elevated by FCA reagent treatment. Excess dose of the methanol extract produced no severe toxicity on the body weight, wet organ weights and hepatic functions. Since $LD_50$ value of K. pictus methanol extract was shown to be 4,033 ${mg/kg}$, it could be estimated to be a safe agent for anti-rheumatoidal herbal medicines.
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Kalopanaxsaponin A from Kalopanax pictus, a Potent Antioxidant in the Rheumatoidal Rat Induced by Freund、s Complete Adjuvant Reagent
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Analgesic Effect of Kalipanax pictus extract and Its Saponin Components, and Their Inhibitory Effect on Freund、s Complete Adjuvant Reagent-Induced Rheumatoidal Arthritis in Animal
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Anticarcinogenic Properties of Kalopanaxsaponin A Isolated from the Stem Bark of Kalopanax pictus
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A Potent Anti-diabetic Agent from Kalopanax pictus
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The anti-inflammatory activity of Kalopanax pictus bark extract (IV). Antirheumatic activity of kalopanaxsaponin A methyl ester
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Anti-inflammatory Effects of Kalopanax pictus Bark and Its Fractions
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The anti-inflammatory activity of Kalopanax pictus bark extract (V). Effects of saponins from KP on $NF-_K/B$ and elastase activities
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Anti-Lipid Peroxidative Principles of the Stem Bark of Kalopanax pictus Nakai
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Vascular Permeability Inhibitory constituents of Kalopanax pictus bark
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The anti-inflammatory activity of Kalopanax pictus bark extract (II). Isolation of pictoside A, a new saponin
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The anti-inflammatory activity of Kalopanax pictus bark extract (III). Anti-inflammatory effects of alkaline hydrolysate from BuOH fraction
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Human Immunodeficiency Virus Type Ⅰ에 대한 음나무 추출물의 억제활성
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Inhibitory Effect of the Extract from the Three Crude Drugs, Kalopanax pictus, Pueraria thunbergiana and Rhus verniciflua on NO and TNF-a production in LPS-induced Macrophage 264.7 Cells
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