Formalin Pretreatment Attenuates Tail-Flick Inhibition Induced by ${beta}$-Endorphin Administered Intracerebroventricularly or Intrathecally in Mice

Han Ki-Jung; Choi Seong-Soo; Shim Eon-Jeong; Seo Young-Jun; Kwon Min-Soo; Lee Jin-Young; Lee Han-Kyu; Suh Hong-Won

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자료유형: 학술저널

저자정보: Han Ki-Jung (Department of Pharmacology, College of Medicine and Institute of Natural Medicine) Choi Seong-Soo (Department of Pharmacology, College of Medicine and Institute of Natural Medicine) Shim Eon-Jeong (Department of Pharmacology, College of Medicine and Institute of Natural Medicine) Seo Young-Jun (Department of Pharmacology, College of Medicine and Institute of Natural Medicine) Kwon Min-Soo (Department of Pharmacology, College of Medicine and Institute of Natural Medicine) Lee Jin-Young (Department of Pharmacology, College of Medicine and Institute of Natural Medicine) Lee Han-Kyu (Department of Pharmacology, College of Medicine and Institute of Natural Medicine) Suh Hong-Won (Department of Pharmacology, College of Medicine and Institute of Natural Medicine)

저널정보: 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제28권 제2호

발행연도: 2005.1

수록면: 227 - 231 (5page)

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We examined the effect of the subcutaneous (s.c.) pretreatment of formalin into both hind paws of mice on the antinociception induced by the intracerebroventricularly (i.c.v.) or intrathecally (i.t.) administration of ${\beta}$-endorphin using the tail-flick test. Pretreatment with formalin ($5\%$) for 5 h had no affect on the i.c.v. administered ${\beta}$-endorphin-induced tail-flick response. However, pretreatment with formalin for 40 h attenuated the tail-flick inhibition induced by i.c.v. administered ${\beta}$-endorphin. This antinociceptive tolerance to i.c.v. ${\beta}$-endorphin continued up to 1 week, but to a lesser extent. Pretreatment with formalin for 5 and 40 h significantly reduced the i.t. ${\beta}$-endorphin-induced inhibition of the tail-flick response, which continued up to 1 week. The s.c. formalin treatment increased the hypothalamic pro-opiomelanocortin (POMC) mRNA level at 2 h, but this returned to the basal level after 40 h. Our results suggest that the increase in the POMC mRNA level in the hypothalamus appears to be involved in the supraspinal or spinal ${\beta}$-endorphin-induced antinociceptive tolerance in formalin-induced inflammatory pain.

#Pro-opiomelanocortin mRNA #Hypothalamus #Formalin #Antinociceptive tolerance

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