General Pharmacological Study of CJ-11828, an Amlodipine adipate

Choi, Jae-Mook; Lee, Sung-Hak; Kim, Il-Hwan; Park, Jie-Eun; Park, Choong-Sil; Youn, Yong-Sik; Lim, Dong-Kwon; Cho, Sung-Hwan; Chang, Jun-Hwan; Do, Sun-Hee; Kim, Eun-Joo; Kim, Young-Hoon

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자료유형: 학술저널

저자정보: Choi, Jae-Mook (R&D Center of Pharmaceuticals, CJ Corp.) Lee, Sung-Hak (R&D Center of Pharmaceuticals, CJ Corp.) Kim, Il-Hwan (R&D Center of Pharmaceuticals, CJ Corp.) Park, Jie-Eun (R&D Center of Pharmaceuticals, CJ Corp.) Park, Choong-Sil (R&D Center of Pharmaceuticals, CJ Corp.) Youn, Yong-Sik (R&D Center of Pharmaceuticals, CJ Corp.) Lim, Dong-Kwon (R&D Center of Pharmaceuticals, CJ Corp.) Cho, Sung-Hwan (R&D Center of Pharmaceuticals, CJ Corp.) Chang, Jun-Hwan (R&D Center of Pharmaceuticals, CJ Corp.) Do, Sun-Hee (Korea Institute of Toxicology) Kim, Eun-Joo (Korea Institute of Toxicology) Kim, Young-Hoon (R&D Center of Pharmaceuticals, CJ Corp.)

저널정보: 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제12권 제2호

발행연도: 2004.1

수록면: 114 - 121 (8page)

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This study was undertaken to evaluate the general pharmacological properties of CJ-11828, an amlodipine adipate, in experimental animals and in vitro system. CJ-11828 had no effects on general behavior, motor coordination, writhing syndromes, pentetrazol-induced chemoshock and electric shock in mice at dose levels of 3,10, anti 30 mg/kg, po. But there were decrease of body temperature, prolongation of sleeping time, and inhibition of intestinal activity in mice treated with CJ-11828 at doses of 10 and 30 mg/kg, po. CJ-11828 decreased the blood pressure in coscuous fog at the dose level of 2mg/kg, po, but it was expected as a result of pharmacological activity of CJ-11828. Any effect on respiratory system was not observed in conscious rat at doses of 3,10, and 30 mg/kg, po. The slight decrease in spontaneous motor activity was observed in mice treated with CJ-11828 at high dose, 30 mg/kg. In vitro experiments, CJ-11828 had no effect on agonists-induced contraction of isolated guinea pig ileum at 0.1, 1, and 10 ${\mu}$M. Based on these results, it was concluded that CJ-11828 had no pharmacological effect ill these studies even up to the 36-fold anticipated clinical dose, 3 mg/kg.

#CJ-11828 #Amlodipine adipate #Anti-hypertension agent #Calcium channel blocker #General pharmacology

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