Influence of FCCP on Catecholamine Release in the Rat Adrenal Medulla

Lim, Dong-Yoon; Jo, Seong-Ho; Kee, Young-Woo; Lim, Ji-Yeon; Choi, Deok-Ho; Baek, Young-Joo; Hong, Soon-Pyo

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자료유형: 학술저널

저자정보: Lim, Dong-Yoon (Department of Pharmacology, College of Medicine, Chosun University) Jo, Seong-Ho (Department of Pharmacology, College of Medicine, Chosun University) Kee, Young-Woo (Department of Pharmacology, College of Medicine, Chosun University) Lim, Ji-Yeon (Department of Pharmacology, College of Medicine, Chosun University) Choi, Deok-Ho (Department of Pharmacology, College of Medicine, Chosun University) Baek, Young-Joo (Department of Pharmacology, College of Medicine, Chosun University) Hong, Soon-Pyo (Department of Internal Medicine [Cardiology], Chosun University)

저널정보: 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제12권 제3호

발행연도: 2004.1

수록면: 165 - 174 (10page)

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이 논문의 연구 히스토리 (9)

2004

Influence of FCCP on Catecholamine Release in the Rat Adrenal Medulla

Lim , Dong-Yoon , Jo 외 11명 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 2004.01 학술저널

2002

Inhibitory Mechanism of Bromocriptine on Catecholamine Release Evoked by Cholinergic Stimulation and Membrane Depolarization from the Rat Adrenal Medulla

Lim , Dong-Yoon , Lee 외 3명 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2002.01 학술저널

Influence of Cytisine on Catecholamine Release in Isolated Perfused Rat Adrenal Glands

Lim , Dong-Yoon , Jang 외 3명 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2002.01 학술저널

Influence of CCCP on Catecholamine Secretion from the Perfused Rat Adrenal Medulla

Lim , Dong-Yoon , Jo 외 3명 대한약학회 학술대회 2002.01 학술대회자료

2001

Influence of Cilnidipine on Catecholamine Release Evoked by Cholinergic Stimulation and Membrane Depolarization in the Perfused Rat Adrenal Gland

Lim , Dong-Yoon , Woo 외 3명 한국응용약물학회 추계학술발표논문집 2001.01 학술대회자료

2000

Influence of 5′-(N′-Ethylcarboxanlido) Adenosine on Catecholarnine Secretion Evoked by Cholinergic Stimulation and Membrane Depolarization in the Rat Adrenal Gland

Lim , Dong-Yoon , Oh 외 3명 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 2000.01 학술저널

Influence of Quinidine on Catecholamine Secretion Evoked by Cholinergic Stimulation and Membrane Depolarization from the Perfused Rat Adrenal Gland

Lim , Dong-Yoon , Jeon 외 11명 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 2000.01 학술저널

1992

Influence of TMB-8 on Secretion of Catecholamines from the Perfused Rat Adrenal Glands

Lim , Dong-Yoon , Kim 외 3명 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 1992.01 학술저널

1991

Studies on Secretion of Catecholamine Evoked by Caffeine from the Isolated Perfused Rat Adrenal Gland

Lim , Dong-Yoon , Lee 외 11명 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 1991.01 학술저널

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The aim of the present study was to investigate the effect of FCCP (carbonyl cyanide p-trifluoromethoxyphenyIhydrazone), which is a potent mitochondrial uncoupler, on secretion of catecholamines (CA) from the perfused model of the rat adrenal gland and to establish the mechanism of its action. The perfusion of FCCP (3 ${\times}$ $10^{-5}$ M) into an adrenal vein of for 90 min resulted in great increases in CA secretions. Tachyphylaxis to CA-releasing effect of FCCP was not observed by repeated perfusion of it. The CA-releasing effects of FCCP were depressed by pre-treatment with pirenzepine, chlorisondamine, nicardipine, TMB-8, and the perfusion of EGTA plus $Ca^{2+}$-free medium. In the presence of FCCP (3 ${\times}$ $10^{-5}$ M), the CA secretory responses induced by Ach (5.32 ${\times}$ $10^{-3}$ M), and DMPP ($10^{-4}$ M) were significantly enhanced. Furthermore, the perfusion of CCCP (3 ${\times}$ $10^{-5}$ M), a similar mitochondrial uncoupler, into an adrenal vein for 90 min also caused an increased response in CA secretion. Taken together these experimental results indicate that FCCP causes the CA secretion the perfused rat adrenal medulla in a calcium-dependent fashion. It is suggested that this facilitatory effects of FCCP may be mediated by cholinergic receptor stimulation, which is relevant to both stimulation of the $Ca^{2+}$ influx and $Ca^{2+}$ release from cytoplasmic $Ca^{2+}$ stores.

#FCCP #carbonylcyanide p-trifluoromethoxyphenylhydrazone) #catecholamine secretion #cholinergic receptor stimulation #adrenal Medulla

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