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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 569 - 577 (9page)
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The physicochemical characteristics and biological activities, including antioxidant activity, antimutagenicity, and cytotoxicity of hot-water extract of fruiting body of Hericium erinaceus, were investigated in this study. Hot-water extract of fruiting body of Hericium erinaceus contained carbohydrate (7.86%), protein (10.91%), and ${\beta}$-glucan (3.62%). Water solubility of hot-water extract was 42.58%. Antioxidant activities of the extract were evaluated by ABTS assay and FRAP assay. The $IC_{50}$ value was 312.21 ${\mu}g/mL$ in ABTS assay. Antimutagenic activity of the extract was evaluated by Ames test. Antimutagenicity of hot-water extract (5 mg/mL) on Salmonella Typhimurium TA100 mutagenated by sodium azide (0.15 ${\mu}g/mg$) was 69.2%. Cytotoxicity of hot-water extract was also evaluated by MTT and SRB assay. The cytotoxicity was highest (83.95%) on Hep3B treated with 2,000 ${\mu}g/mL$ of hot-water extract in SRB assay. Therefore, it is suggested that hot-water extract of fruiting body of Hericium erinaceus has high antioxidant activity, antimutagenicity, and cytotoxicity.
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참고문헌 (37)
참고문헌 신청
농촌진흥청 농업과학기술원 / 2004 / 한국의 버섯-식용버섯과 독버섯 / 동방미디어 :264~265
성낙계 / 2005 / 암을 이기는 신비의 상황버섯 다당체 / 북랜드 :170~187
Benzie F / 1996 / The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power" :The FRAP assay / J Anal Bio Chem 239(1):70~76
Bradford MM / 1976 / A rapid, sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biol Chem 72:248~254
Carmichael J / 1987 / Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing / Can Res 47:936~942
성낙계 / 2005 / 암을 이기는 신비의 상황버섯 다당체 / 북랜드 :170~187
Benzie F / 1996 / The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power" :The FRAP assay / J Anal Bio Chem 239(1):70~76
Bradford MM / 1976 / A rapid, sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biol Chem 72:248~254
Carmichael J / 1987 / Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing / Can Res 47:936~942
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