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논문 기본 정보

자료유형
학술저널
저자정보
박화용 (한국한의학연구원 신한방제제연구센터) 유현주 (한국한의학연구원 체질생물학의공학연구센터) 구임회 (한국한의학연구원 체질생물학의공학연구센터) 김종열 (한국한의학연구원 체질생물학의공학연구센터)
저널정보
사상체질의학회 사상체질의학회지 사상체질의학회지 제21권 제1호
발행연도
2009.1
수록면
227 - 236 (10page)

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1. Objectives As a basic trial for identification of Sasang constitutional gene marker, we genotyped and analysed statistical relationships of STR(short tandem repeat) alleles and its distribution in each constitution. 2. Methods After obtaining basic constitutional data with questionnaire (QSCC II), decision of constitution was made by 3 different constitution specialists' diagnosis, and only the samples of specialists' agreement of each constitution by discussion were taken into this research. Using multiplex PCR kit, total 146 constitutional samples were amplified in 16 autosomal STR marker, genotyped, and analysed statistically. Among 16 markers, 15 were analysed in this study excluding the amelogenin marker is used for in gender identification. 3. Results and Conclusions It is difficult to determine the relationship between constitution and STR marker as the sample size is small, however, Penta D and vWA were shown to be related statistically with constitution. It has been know that STRs has no genetic informations, however there are some recent research results showing STRs as a regulatory element, relationship between microsatellite instability and repeat number and size, and post-transcriptional sigualing. STRs which is not known about its function currently, are proposed to have function and/or regulatory activities anyhow with Sasang constitution. It is believed that the results of this study can halp determine and deatify the markers related to Sasang Constitutional Medicien.

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