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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 17 - 29 (13page)
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초록· 키워드
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Inflammatory and oxidative stimuli play a critical role not only in the process of transforming normal cells into cancer cells, but also in the proliferation process of cancer cells. Sipyukmiryukieum (SYMRKU), a traditional Korean herb-combined remedy, is composed of 16 kinds of herbal medicines, which were recorded for "Ongjeo" treatment in "Dongeuibogam". In this study, we investigated the inhibitory effect of SYMRKU against inflammatory and oxidative responses in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Our results showed that SYMRKU significantly inhibited LPS-induced secretion of pro-inflammatory mediators including nitric oxide (NO) and prostaglandin $E_2$ without showing any significant cytotoxicity. Consistent with these results, SYMRKU down-regulated LPS-induced expression of their regulatory enzymes such as inducible NO synthase and cyclooxygenase-2. SYMRKU also inhibited LPS-induced production and expression of pro-inflammatory cytokines such as tumor necrosis factor-${\alpha}$, interleukin (IL)-$1{\beta}$ and IL-6. In addition, SYMRKU significantly reduced the production of reactive oxygen species by LPS and showed a strong, which was associated with induction of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 expression. Although further studies are needed to fully understand the anti-inflammatory effects associated with the antioxidant capacity of SYMRKU, the findings of the current study suggest that SYMRKU may have potential benefits by inhibiting the onset and/or treatment of inflammatory and/or oxidative diseases.
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참고문헌 (31)
참고문헌 신청
Giudice A. / 2010 / Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents / Methods Mol Biol 647:37~74
Brown KL / 2007 / Complexities of targeting innate immunity to treat infection / Trends Immunol 28:260~266
Albina JE / 1995 / Nitric oxide in inflammation and immunity / New Horizons 3:46~64
Lee SJ / 2008 / Phytoglycoprotein inhibits in terleu kin - 1β an d in terleukin- 6 via p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated RAW264.7cells / Naunyn-Schmiedebergs Arch Pharmacol 377:45~54
Radi R / 1991 / The cytotoxic potential of superoxide and nitric oxide / J Biol Chem 266:4244~4250
Brown KL / 2007 / Complexities of targeting innate immunity to treat infection / Trends Immunol 28:260~266
Albina JE / 1995 / Nitric oxide in inflammation and immunity / New Horizons 3:46~64
Lee SJ / 2008 / Phytoglycoprotein inhibits in terleu kin - 1β an d in terleukin- 6 via p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated RAW264.7cells / Naunyn-Schmiedebergs Arch Pharmacol 377:45~54
Radi R / 1991 / The cytotoxic potential of superoxide and nitric oxide / J Biol Chem 266:4244~4250
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