지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 797 - 806 (10page)
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초록· 키워드
오류제보하기
Probiotics are live microbes that confer health benefits on the host when administered in adequate amounts. To evaluate the probiotic potential of Bacillus subtilis isolated from Korean fermented foods, we investigated the resistance to biological barriers and improvement of loperamide-induced constipation. The values of resistance to gastric acidity of B. subtilis CBD2 and KMKW4 strains were $55.34{\pm}2.12$ and $64.58{\pm}2.95%$, respectively, whereas the survival rate of B. subtilis KMKW4 ($31.17{\pm}5.78%$) in bile acids was superior to that of CBD2 ($8.62{\pm}2.09%$). These strains also demonstrated adhesiveness to intestinal epithelial HT-29 cells and an inhibitory activity against pathogenic microflora. Furthermore, B. subtilis CBD2 and KMKW4 strains improved gastrointestinal activity when tested in a loperamide-induced mouse model of constipation. Pre-treatment with CBD2 and KMKW4 strains before the onset of constipation improved fecal output and gastrointestinal transit in loperamide-treated mice. These strains also showed inhibitory effects on the activity of ${\beta}$-glucosidase and tryptophanase, harmful enzymes of intestinal microflora. Taken together, these finding show that B. subtilis CBD2 and KMKW4 have high adaptability to gastrointestinal environment, and the ability to inhibit pathogenic microflora and prevent constipation, suggesting their activity as potential probiotics.
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