경피 약물전달을 위한 HA-PLGA 나노입자가 저장된 젤라틴 나노섬유 복합체 개발

이소윤; 정우엽; 이진홍; 김한성; 김기수

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자료유형: 학술저널

저자정보: 이소윤 (부산대학교 유기소재시스템공학과) 정우엽 (부산대학교 유기소재시스템공학과) 이진홍 (부산대학교 유기소재시스템공학과) 김한성 (부산대학교 유기소재시스템공학과) 김기수 (부산대학교 유기소재시스템공학과)

저널정보: 한국섬유공학회 한국섬유공학회지 한국섬유공학회지 제56권 제3호

발행연도: 2019.1

수록면: 155 - 161 (7page)

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In recent years, transdermal drug delivery system (TDDS) has emerged as an alternative to needle injection. TDDS offers various benefits including being noninvasive and encouraging patient compliance; however, the skin barrier, stratum corneum, prevents sufficient penetration of drugs through the skin. In this work, we have designed hyaluronic acid-poly(lactic-co-glycolic acid) nanoparticle (HA-PLGA NP)-incorporated gelatin nanofiber (GE NF/HA-PLGA) complexes for the sustained release of drugs and to avoid drug degradation in TDDS. The HA-PLGA NPs were prepared by water-in-oil-in-water (W/O/W) solvent evaporation method, while the GE NFs were fabricated by electrospinning. The successful formation of HA-PLGA NPs were confirmed by proton nuclear magnetic resonance, transmission electron microscopy, and dynamic light scattering, while that of the NFs were confirmed by field emission scanning electron microscopy and Fourier-transform infrared spectroscopy. The results of in vitro release tests reveal that the GE/HA-PLGA complex shows delayed and extended release of drugs. The histological analysis demonstrates that the HA-PLGA NPs can be released from the GE NFs and penetrate the skin. These results indicate the feasibility of using GE/HA-PLGA complexes as a suitable candidate for novel TDDS.

#hyaluronic acid #poly #lactic-co-glycolic acid) #nanoparticle #gelatin nanofiber #transdermal drug delivery

참고문헌 (25)

참고문헌 신청

M. R. Prausnitz / 2008 / Transdermal Drug Delivery / Nat. Biotechnol 26:1261~1268

A. Z. Alkilani / 2015 / Transdermal Drug Delivery : Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum / Pharmaceutics 7:438~470

S. Bjőrklund / 2010 / A Water Gradient Can be Used to Regulate Drug Transport Across Skin / J. Controlled Release 143:191~200

B. C. Palmer / 2016 / Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting / Molecules 21:1719

H. Marwah / 2016 / Permeation Enhancer Strategies in Transdermal Drug Delivery / Drug Deliv 23:564~578

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