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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 51 - 58 (8page)
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초록· 키워드
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Objectives : Pinus densiflora gnarl, called Song-Jeol in Korean medicine, has been used to cure inflammatory diseases such as arthritis. In the present study, we evaluated inhibitory property of Song-Jeol pharmacopuncture(SJ) on C6 glioma cell migration. Methods : To evaluate cell viability on C6 glioma cells of SJ, the viability was assessed by using Ez-cytox assay kit. The cell migration was assessed by wound-healing assay and Boyden chamber assay, respectively. LPS-induced NO productions were determined by using the Griess reagent. The expression of iNOS and protein kinase $C(PKC)-{\alpha}$ were estimated by western blotting assay. Results : In the wound-healing assay and Boyden chamber assay, SJ showed a significant inhibition on serum-induced C6 glioma cell migration. In addition, NO production was decreased by SJ through suppression of iNOS expression in LPS-stimulated C6 glioma cell. Futhermore, LPS-induced protein kinase $C(PKC)-{\alpha}$ expression was effectively inhibited by SJ. Conclusions : These results demonstrated that SJ was useful for the suppression of the C6 glioma cell migration.
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참고문헌 (35)
참고문헌 신청
Zhou F / 2014 / Proline-rich protein 11 regulates epithelial-to-mesenchymal transition to promote breast cancer cell invasion / Int J Clin Exp Pathol 7(12):8692~8699
De Vita F / 2014 / Clinical management of advanced gastric cancer: the role of new molecular drugs / World J Gastroenterol 20(40):14537~14558
Mariani F / 2014 / Inflammatory pathways in the early steps of colorectal cancer development / World J Gastroenterol 20(29):9716~9731
Kibler JL / 2014 / Metabolic, autonomic and immune markers for cardiovascular disease in posttraumatic stress disorder / World J Cardiol 6(6):455~461
Brink E / 2012 / Considering both health-promoting and illness-related factors in assessment of health-related quality of life after myocardial infarction / Open Nurs J 6:90~94
De Vita F / 2014 / Clinical management of advanced gastric cancer: the role of new molecular drugs / World J Gastroenterol 20(40):14537~14558
Mariani F / 2014 / Inflammatory pathways in the early steps of colorectal cancer development / World J Gastroenterol 20(29):9716~9731
Kibler JL / 2014 / Metabolic, autonomic and immune markers for cardiovascular disease in posttraumatic stress disorder / World J Cardiol 6(6):455~461
Brink E / 2012 / Considering both health-promoting and illness-related factors in assessment of health-related quality of life after myocardial infarction / Open Nurs J 6:90~94
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