지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The aim of present study was to investigate the possible influence and related mechanism of resveratrol on U-46619 (high concentration)-induced vasoconstriction. Agonist-induced vascular smooth muscle contractions involve the activation of thick or thin filament pathway. However, there are no reports addressing the question whether this pathway is involved in resveratrol-induced relaxation in rat aortae contracted with high U-46619. We hypothesized that MEK or Rho-kinase inhibition plays a role in vascular relaxation evoked by resveratrol in rat aortae. Endothelium-denuded arterial rings from male Sprague-Dawley rats were used and isometric contractions were recorded using a computerized data acquisition system. Resveratrol fully inhibited U-46619 in low concentration-induced contraction regardless of endothelial function. However, resveratrol partially decreased U-46619 in high concentration-induced contraction regardless of endothelial function. Interestingly, only in U-46619 (high concentration)-induced contraction, no significant decrease was observed in phospho-ERK1/2 levels and slight decrease in phospho-MYPT1 levels suggesting that additional pathways different from them or endothelial nitric oxide synthesis might be involved in the vasorelaxation. In conclusion, in high U-46619-contracted rat aortae, resveratrol showed relaxation response regardless of endothelial function significantly but slightly decreasing MYPT1 phosphorylation rather than ERK1/2 phosphorylation.
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참고문헌 (23)
참고문헌 신청
Benavente-Garcia, O / 1997 / J. Agri. Food Chem 45:4505
Hain, R. / 1990 / Expression of a stilbene synthase gene in Nicotiana tabacum results in synthesis of the phytoalexin resveratrol / Plant Mol. Biol 15:325
Hain, R / 1993 / Disease resistance results from foreign phytoalexin expression in a novel plant / Nature 361:153
Bhat, K. P. L / 2002 / Cancer chemopreventive activity of resveratrol / Ann. N.Y. Acad. Sci 957:210
Pervaiz, S / 2003 / Resveratrol: From grapevines to mammalian biology / FASEB J 17:1975
Hain, R. / 1990 / Expression of a stilbene synthase gene in Nicotiana tabacum results in synthesis of the phytoalexin resveratrol / Plant Mol. Biol 15:325
Hain, R / 1993 / Disease resistance results from foreign phytoalexin expression in a novel plant / Nature 361:153
Bhat, K. P. L / 2002 / Cancer chemopreventive activity of resveratrol / Ann. N.Y. Acad. Sci 957:210
Pervaiz, S / 2003 / Resveratrol: From grapevines to mammalian biology / FASEB J 17:1975
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