지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Abnormal growth of adipocyte characterized by increased cell numbers and differentiation is considered as an major pathological characteristic feature in obesity. Thus, inhibition of mitogenesis of preadipocytes and their differentiation to adipocytes would be beneficial for the prevention and inhibition of obesity. In the present study, we attempted to evaluate anti-adipogenic activity of eggplants (the fruits of Solanum melongena L.) employing preadipocytes cell line, 3T3-L1 as an in vitro assay system. Water extract of eggplants significantly inhibited adipocyte differentiation when treated during adipocyte differentiation process, as assessed by measuring fat accumulation using Oil Red O staining. Eggplant extract, however, showed little effects on fully differentiated adipocytes. Eggplant didn't show significant toxicity up to 500 ${\mu}g$/ml to the 3T3-L1 cells. Further studies with interval treatment demonstrated that eggplant exerted inhibitory activity on adipocyte differentiation via acting on early stage of adipogenesis. Conclusively, eggplants are suggested to be beneficial for the prevention of obesity.
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참고문헌 (20)
참고문헌 신청
Grundy, S. M / 1998 / Multifactorial causation of obesity: implications for prevention / Am. J. Clin. Nutr 67:563s
Bastard, J. P / 2006 / Recent advances in the relationship between obesity, inflammation and insulin resistance / Eur. Cytokine Netw 17:4
Kopelman, P. G / 2000 / Obesity as a medical problem / Nature 404:635
Rayalam, S / 2008 / Phytochemicals and regulation of the adipocyte life cycle / J. Nutr. Biochem 19:717
Spielgelman, B. M / 2006 / The adipocyte: a multifunctional cell / Cell Metab 4:425
Bastard, J. P / 2006 / Recent advances in the relationship between obesity, inflammation and insulin resistance / Eur. Cytokine Netw 17:4
Kopelman, P. G / 2000 / Obesity as a medical problem / Nature 404:635
Rayalam, S / 2008 / Phytochemicals and regulation of the adipocyte life cycle / J. Nutr. Biochem 19:717
Spielgelman, B. M / 2006 / The adipocyte: a multifunctional cell / Cell Metab 4:425
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