지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Induction of effective and increased levels of antibody production may be major points in vaccine development. This is especially the case when the antigenic sources are carbohydrates. Thus, in our Lab various types of formulations such as liposomal and conjugate vaccines have been researched. However, the fastidious formulation process and high costs are a problem. For this reason, there is currently a focus on utilizing immunoadjuvants. In this present study, we tested whether ginsenosides Re (a panaxdiol) and Rg1 (a panaxtriol) from Panax ginseng have immunoadjuvant activity against the cell wall of Candida albicans (CACW). The resulting data showed that Rd and Rg1 caused LPS-treated B lymphocytes to be proliferative. Rd had greater proliferation activity than that of Rg1. In the murine model of antibody production, CACW combined with Rd [CACW/Rd/IFA] or Rg1 [CACW/Rg1/IFA] increased the production of antibodies specific to C. albicans when compared to the antibody production by [CACW/IFA]-induction, which was used as a negative control (P<0.05). In the case of [CFA/Rd/IFA], the antibody production was almost twice as that of the CFA. In addition, formulations containing either had a prolonged antibody inducing activity as compared to the CFA formula. In conclusion, Rd and Rg1 have an immunologic activity, and yet Rd can be a better candidate than Rg1 for a new immunoadjuvant.
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참고문헌 (36)
참고문헌 신청
Ronin, C. / 1998 / Remodeling of glycoprotein and carbohydrate antigens / Clin. Chem. Lab. Med 36:373
Ravdin, J. I / 1993 / Antigenicity, immunogenicity and vaccine efficacy of the galactose-specific adherence protein of Entamoeba histolytica / Vaccine 11:241
Han, Y / 1995 / Antibody response that protects against disseminated candidiasis / Infect. Immun 63:2714
Han, Y / 1999 / Candida albicans mannan extract-protein conjugates induce a protective immune response against experimental candidiasis / J. Infect. Dis 179:1477
Schijns, V. E / 2011 / Trends in vaccine adjuvants. Expert. Rev / Vaccines 10:539
Ravdin, J. I / 1993 / Antigenicity, immunogenicity and vaccine efficacy of the galactose-specific adherence protein of Entamoeba histolytica / Vaccine 11:241
Han, Y / 1995 / Antibody response that protects against disseminated candidiasis / Infect. Immun 63:2714
Han, Y / 1999 / Candida albicans mannan extract-protein conjugates induce a protective immune response against experimental candidiasis / J. Infect. Dis 179:1477
Schijns, V. E / 2011 / Trends in vaccine adjuvants. Expert. Rev / Vaccines 10:539
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