지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Cyanidin-3-glucoside (C3G), an anthocyanin, is one of the most widespread dietary flavonoids. We investigated the effects of C3G in PMA/ionomycin (PI)-induced RBL-2H3 cells. C3G inhibited the production of IL-4 and IL-13 and also decreased the level of mRNA in a dose-dependent manner. Furthermore, western blot analysis implied that C3G down-regulated the protein level of c-Jun, NF-ATc1 and NF-${\kappa}B$ but not c-Fos. Taken together, we suggest that C3G may have suppressive effects on Th2 cytokines and will be studied further to develop as functional foods that help alleviate allergy symptoms.
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참고문헌 (29)
참고문헌 신청
Passante, E / 2009 / RBL-2H3 cells are an imprecise model for mast cell mediator release / Inflamm Res 58:611
Schuijs, M. J / 2013 / Cytokine targets in airway inflammation / Curr. Opin. Pharmacol 13:351
Brusselle, G. G / 1994 / Attenuation of allergic airway inflammation in IL-4 deficient mice / Clin. Exp. Allergy 24:73
Zavorotinskaya, T / 2003 / Treatment of experimental asthma by long-term gene therapy directed against IL-4 and IL-13 / Mol. Ther 7:155
Gallo, E / 2012 / IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens / Eur. J. Immunol 42:2322
Schuijs, M. J / 2013 / Cytokine targets in airway inflammation / Curr. Opin. Pharmacol 13:351
Brusselle, G. G / 1994 / Attenuation of allergic airway inflammation in IL-4 deficient mice / Clin. Exp. Allergy 24:73
Zavorotinskaya, T / 2003 / Treatment of experimental asthma by long-term gene therapy directed against IL-4 and IL-13 / Mol. Ther 7:155
Gallo, E / 2012 / IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens / Eur. J. Immunol 42:2322
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