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In this study, we examined the effect of acacetin on the apoptosis induction of HeLa human cervical cancer cells. The results showed that acacetin inhibited the cell viability and induced apoptosis, leading to PARP cleavage and activation of caspase-9, -3, and -7. Moreover, acacetin-induced apoptosis was attenuated by a broad caspase inhibitor, z-VAD-fmk. Also, acacetin resulted in a loss of mitochondria membrane potential. Taken together, our results demonstrate that the induction of apoptosis by acacetin in HeLa cells is associated with caspase activation via the mitochondria pathway.
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참고문헌 (21)
참고문헌 신청
Korea National Statistical Office / 2014 / Annual report of cancer statistics in Korea in 2012
Waggoner, S. E / 2003 / Cervical cancer / Lancet 361:2217
Fujimoto, J / 2009 / Novel strategy of anti-angiogenic therapy for uterine cervical carcinomas / Anticancer Res 29:2665
Van Cruchten, S / 2002 / Morphological and biochemical aspects of apoptosis, oncosis and necrosis / Anat. Histol. Embryol 31:214
Elmore, S / 2007 / Apoptosis: a review of programmed cell death / Toxicol. Pathol 35:495
Waggoner, S. E / 2003 / Cervical cancer / Lancet 361:2217
Fujimoto, J / 2009 / Novel strategy of anti-angiogenic therapy for uterine cervical carcinomas / Anticancer Res 29:2665
Van Cruchten, S / 2002 / Morphological and biochemical aspects of apoptosis, oncosis and necrosis / Anat. Histol. Embryol 31:214
Elmore, S / 2007 / Apoptosis: a review of programmed cell death / Toxicol. Pathol 35:495
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