지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Angelica gigas is one of the most widely used herbal medicines in Asia. Root extract of Angelica gigas is known to have anti-oxidant activity and skin whitening effect. The aim of this study was to prepare microemulsion system of root extracts of Angelica gigas for topical delivery. Microemulsion was successfully prepared by using MCT (medium chain triglyceride) as an oil phase, Labrasol as a surfactant, and the mixture of propyleneglycol and phosphatidylcholine (4 : 1) as a cosurfactant. In vitro and in vivo skin permeation and deposition of decursin, as a marker, was determined using hairless mouse. Microemulsion significantly increased the in vitro skin permeation of decursin for up to 12 hours and was significantly higher than the control (water). Moreover, microemulsion formulation showed significantly higher skin deposition of decursin compared to the control in both in vitro and in vivo studies. Thus, microemulsion could be a useful vehicle for topical application of root extracts of Angelica gigas.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ahn, M. J. / 2008 / The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry / J. Pharm. Biomed. Anal 46:258
Choi, S. S. / 2003 / Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models / Biol. Pharm. Bull 26:1283
Kohen, R. / 1999 / Skin antioxidants: their role in aging and in oxidative stress--new approaches for their evaluation / Biomed. Pharmacother :181
박숙경 / 2009 / 참당귀(Angelica gigas Nakai) 뿌리 추출물의 화장품소재 특성 / Korean Chemical Engineering Research(HWAHAK KONGHAK) 47(5):553~557
Tenjarla, S. / 1999 / Microemulsions: an overview and pharmaceutical applications / Crit. Rev. Ther. Drug Carrier Syst 16:461
Choi, S. S. / 2003 / Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models / Biol. Pharm. Bull 26:1283
Kohen, R. / 1999 / Skin antioxidants: their role in aging and in oxidative stress--new approaches for their evaluation / Biomed. Pharmacother :181
박숙경 / 2009 / 참당귀(Angelica gigas Nakai) 뿌리 추출물의 화장품소재 특성 / Korean Chemical Engineering Research(HWAHAK KONGHAK) 47(5):553~557
Tenjarla, S. / 1999 / Microemulsions: an overview and pharmaceutical applications / Crit. Rev. Ther. Drug Carrier Syst 16:461
이 논문의 저자 정보
최근 본 자료
댓글(0)
0