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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Citrate-capped silver nanoparticles (AgNPs) are widely used in industry, consumer products and medical appliances. However, information on the toxicity, environmental fate and toxicokinetics are not enough. In this study, stability of citrate-capped AgNPs was investigated using different types of isotonic solution, which is important in the toxicokinetic study by the exposure route of intravenous injection. Size, morphology, zeta potential and ion formation were investigated in isotonic solutions for the physico-chemical characterization of AgNPs. Aggregation and precipitation of AgNPs were observed in saline or phosphate-buffered saline while they were stable without precipitation in 2% glycerol of isotonic solution. The average size of AgNPs in 2% glycerol was 6~10 nm, which was almost same as that in water-based suspension of AgNPs. Zeta potential was ranged from -30 mV to -60 mV, which was in the range of original stock AgNPs. The stability was maintained during the whole experimental period of 48 hours. Furthermore, the stability was not changed in different temperature (10~36$^{\circ}C$) and at different concentrations (10~1,000 ppm). The osmolarity of the AgNPs suspension was $299{\pm}1$ mOsm/kg which was in isotonic range. These data suggest that AgNPs in 2% glycerol solution can be used for the preparations of intravenous injection for toxicokinetic study without undesired disturbance of blood isotonicity.
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참고문헌 (20)
참고문헌 신청
Chen, X. / 2008 / Nanosilver: a nanoproduct in medical application / Toxicol. Lett 176:1
Lem, K. W. / 2012 / Use of nanosilver in consumer products / Recent Pat. Nanotechnol 6:60
Ahamed, M. / 2010 / Silver nanoparticle applications and human health / Clin. Chim. Acta 411:1841
Quadros, M. E. / 2010 / Environmental and human health risks of aerosolized silver nanoparticles / J. Air Waste Manag. Assoc 60:770
Hsin, Y. H. / 2008 / The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells / Toxicol. Lett 179:130
Lem, K. W. / 2012 / Use of nanosilver in consumer products / Recent Pat. Nanotechnol 6:60
Ahamed, M. / 2010 / Silver nanoparticle applications and human health / Clin. Chim. Acta 411:1841
Quadros, M. E. / 2010 / Environmental and human health risks of aerosolized silver nanoparticles / J. Air Waste Manag. Assoc 60:770
Hsin, Y. H. / 2008 / The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells / Toxicol. Lett 179:130
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