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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Min-Jung (National Research Laboratory of Lipid Metabolism & Atherosclerosis, KRIBB, College of Pharmacy, Chungnam National University) Han, Jong-Min (National Research Laboratory of Lipid Metabolism & Atherosclerosis, KRIBB) Jin, Yue-Yan (National Research Laboratory of Lipid Metabolism & Atherosclerosis, KRIBB) Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center,Kyung Hee University) Bang, Myun-Ho (Graduate School of Biotechnology & Plant Metabolism Research Center,Kyung Hee University) Chung, Hae-Gon (Gangwha Agricultural R&D Center) Choi, Myung-Sook (Department of Food Science & Nutrition, Kyungpook National University) Lee, Kyung-Tae (College of Pharmacy, Kyung Hee University) Sok, Dai-Eun (College of Pharmacy, Chungnam National University) Jeong, Tae-Sook (National Research Laboratory of Lipid Metabolism & Atherosclerosis, KRIBB)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제4호
발행연도
2008.1
수록면
429 - 437 (9page)

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Oxidized low-density lipoprotein (oxLDL) plays a key role in the inflammatory processes of atherosclerosis. Jaceosidin isolated from the methanolic extracts of the aerial parts of Artemisia princeps Pampanini cv. Sajabal was tested for antioxidant and anti-inflammatory activities. Jaceosidin inhibited the $Cu^{2+}-mediated$ LDL oxidation with $IC_{50}$ values of 10.2 ${\mu}M$ in the thiobarbituric acid-reactive substances (TBARS) assay as well as the macrophage-mediated LDL oxidation. The antioxidant activities of jaceosidin were exhibited in the conjugated diene production, relative electrophoretic mobility, and apoB-100 fragmentation on copper-mediated LDL oxidation. Jaceosidin also inhibited the generation of reactive oxygen species (ROS) concerning in regulation of $NF-{\kappa}B$ signaling. And jaceosidin inhibited nuclear factor-kappa B $(NF-{\kappa}B)$ activity, nitric oxide (NO) production, and suppressed expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-induced RAW264.7 macrophages.

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