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논문 기본 정보

자료유형
학술저널
저자정보
Lee, Dong-Sung (Hanbang Body-Fluid Research Center, Wonkwang University) Keo, Samell (Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University) Ko, Wonmin (Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University) Kim, Kyoung-Su (Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University) Ivanova, Elena (Institute for Biological Problems of Cryolithozone [IBPC]) Yim, Joung Han (Korea Polar Research Institute, KORDI) Kim, Youn-Chul (Hanbang Body-Fluid Research Center, Wonkwang University) Oh, Hyuncheol (Hanbang Body-Fluid Research Center, Wonkwang University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제37권 제7호
발행연도
2014.1
수록면
947 - 954 (8page)

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8-Epiloganin (1), mussaenoside (2), and 5-O-caffeoylshikimic acid (3) have been isolated from Castilleja rubra, and the anti-inflammatory properties of these metabolites in a cell culture system were investigated. Compounds 1-3 suppressed not only the production of nitric oxide (NO) and prostaglandin $E_2$, but also the expression of inducible NO synthase and cyclooxygenase-2 induced by lipopolysaccharide (LPS) in the RAW264.7 murine macrophage cell line. Compounds 1-3 also inhibited the release of pro-inflammatory cytokines induced by LPS, namely, tumor necrosis factor-${\alpha}$ and interleukin-$1{\beta}$. The underlying mechanism of the anti-inflammatory action of compounds 1-3 was associated with downregulation of nuclear factor-${\kappa}B$.

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