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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Beom-Su (Laboratory of Enzyme Technology, College of Natural Science, Chonbuk National University) Kim, Cheol-Sang (Division of Mechanical Design Engineering, College of Engineering, Chonbuk National University) Lee, Kang-Min (Laboratory of Enzyme Technology, College of Natural Science, Chonbuk National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제8호
발행연도
2008.1
수록면
1,050 - 1,054 (5page)

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In this study, we prepared chitosan-coated Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles. Specifically, we utilized a double emulsion-solvent evaporation technique to formulate nanoparticles containing paclitaxel as a model macromolecule and 6-coumarin as a fluorescent marker. SEM images verified that all nanoparticles were spherical in shape with smooth surfaces. Chitosan coating slightly increased the size distribution of the PLGA/PVA nanoparticles, from $202.2\;{\pm}\;3.2\;nm$ to $212.2\;{\pm}\;2.9\;nm$, but the encapsulation efficiency was not significantly different. In contrast, coating with chitosan slowed the in vitro drug release rate and significantly changed the zeta potential from negative ($-30.1\;{\pm}\;0.6\;mV$) to positive ($26\;{\pm}\;1.2\;mV$). At the initial burst time, the drug release rate from chitosancoated nanoparticles was slightly slower than that of the uncoated nanoparticles. Chitosan-coated nanoparticles were also taken up much more efficiently than uncoated nanoparticles. This study demonstrated the efficacy of chitosancoated PLGA nanoparticles as an efficient delivery system.

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