Paroxetine Hydrochloride Controlled Release $POLYOX^{(R)}$ Matrix Tablets: Screening of Formulation Variables using Plackett-Burman Screening Design

Jin, Shun-Ji; Yoo, Yeon-Hee; Kim, Min-Soo; Kim, Jeong-Soo; Park, Jeong-Sook; Hwang, Sung-Joo

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자료유형: 학술저널

저자정보: Jin, Shun-Ji (National Research Laboratory of Pharmaceutical Technology, College of Pharmacy, Chungnam National University) Yoo, Yeon-Hee (National Research Laboratory of Pharmaceutical Technology, College of Pharmacy, Chungnam National University) Kim, Min-Soo (National Research Laboratory of Pharmaceutical Technology, College of Pharmacy, Chungnam National University) Kim, Jeong-Soo (National Research Laboratory of Pharmaceutical Technology, College of Pharmacy, Chungnam National University) Park, Jeong-Sook (National Research Laboratory of Pharmaceutical Technology, College of Pharmacy, Chungnam National University) Hwang, Sung-Joo (National Research Laboratory of Pharmaceutical Technology, College of Pharmacy, Chungnam National University)

저널정보: 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제3호

발행연도: 2008.1

수록면: 399 - 405 (7page)

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The aim of the present study was to screen the effects of the formulation variables - $POLYOX^{(R)}$ molecular weight $(X_1)$, the ratio of $POLYOX^{(R)}$/$Avicel^{(R)}$ PH102 $(X_2)$ and the amount of $POLYOX^{\circledR}$ and $Avicel^{\circledR}$ PH102 $(X_3)$, hardness $(X_4)$, HPMCP amount $(X_5)$, $Eudragit^{(R)}$ L100 amount $(X_6)$, and citric acid amount $(X_7)$ - on the paroxetine hydrochloride release from $POLYOX^{(R)}$ matrix tablet using the Plackett-Burman screening design. Paroxetine hydrochloride matrix tablets were prepared according to a 7-factor-12-run statistical model and subjected to a 8-h dissolution study in Tris buffer at pH 7.5. The regression results showed that $POLYOX^{(R)}$ molecular weight $(X_1)$ and $POLYOX^{(R)}$/$Avicel^{(R)}$ PH102 ratio $(X_2)$ had significantly influence on the drug release mechanism and drug release rate as main effects. Hardness $(X_4)$ had an insignificant effect on the drug release mechanism but a significant effect on the drug release rate. On the other hand, HPMCP, $Eudragit^{(R)}$ L100 and citric acid had an insignificant effect on the both responses. The information obtained by screening design study can be expected to be useful for further formulation studies.

#Paroxetine hydrochloride$POLYOX^{ #R)}$ #Plackett-Burman screening design #Controlled release

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