지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Ferritin is an evolutionarily conserved protein that plays an important role in iron storage and detoxification. In this study, the gene encoding a ferritin H subunit homologue (RbFH) was cloned from rock bream (Oplegnathus fasciatus) and analyzed at the expression. The full-length ferritin H cDNA was 1162 bp long and contained an open reading frame (ORF) of 531 bp that encoded 177 amino acid residues with a predicted molecular mass of 20.8 kDa. The 5' UTR was 297 bp in length, and the 3' UTR 298 bp, and preceded by a 5'-untranslated region that contains a putative Iron Regulatory Element (IRE). The deduced amino acid sequence of RbFH shares extensive sequence identities with the H ferritins of a number of fish species and contains the ferroxidase center that is preserved in ferritin H subunits. Examination of tissue specific expression indicated that RbFH expression was most abundant in PBLs, RBC, liver and muscle.
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참고문헌 (30)
참고문헌 신청
Andersen, O. / 1995 / Two ferritin subunits of Atlantic salmon (Salmo salar) : cloning of the liver cDNAs and antibody preparation / Mol. Mar. Biol. Biotechnol 4:164~170
Andrews, SC. / 1992 / Structure, function, and evolution of ferritins / J. Inorg. Biochem 47:161~174
Baker, H.M. / 2003 / Dealing with iron : common structural principles in proteins that transport iron and heme / Proc. Natl. Acad. Sci. USA 100:3579~3583
Cairo, G. / 1991 / Expression of the genes for the ferritin H and L subunits in rat liver and heart : evidence for tissue-specific regulations at pre-and post-translational levels / Biochem. J 275:813~816
Dunkov, B. / 2006 / Insect iron binding proteins : insights from the genomes / Insect Biochem. Mol. Biol 36:300~309
Andrews, SC. / 1992 / Structure, function, and evolution of ferritins / J. Inorg. Biochem 47:161~174
Baker, H.M. / 2003 / Dealing with iron : common structural principles in proteins that transport iron and heme / Proc. Natl. Acad. Sci. USA 100:3579~3583
Cairo, G. / 1991 / Expression of the genes for the ferritin H and L subunits in rat liver and heart : evidence for tissue-specific regulations at pre-and post-translational levels / Biochem. J 275:813~816
Dunkov, B. / 2006 / Insect iron binding proteins : insights from the genomes / Insect Biochem. Mol. Biol 36:300~309
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