악성 종양 관련 일측성 성대 마비 환자에서 고식적 Hyaluronic Acid 성대 주입 성형술의 유용성

김고운; 박영학; 주영훈; 김상연; 심미란; 황연신; 선동일

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자료유형: 학술저널

저자정보: 김고운 (가톨릭대학교 의과대학 서울성모병원 이비인후-두경부외과학교실) 박영학 (가톨릭대학교 의과대학 여의도성모병원 이비인후-두경부외과학교실) 주영훈 (가톨릭대학교 의과대학 부천성모병원 이비인후-두경부외과학교실) 김상연 (가톨릭대학교 의과대학 서울성모병원 이비인후-두경부외과학교실) 심미란 (가톨릭대학교 의과대학 서울성모병원 이비인후-두경부외과학교실) 황연신 (가톨릭대학교 의과대학 서울성모병원 이비인후-두경부외과학교실) 선동일 (가톨릭대학교 의과대학 서울성모병원 이비인후-두경부외과학교실)

저널정보: 대한후두음성언어의학회 대한후두음성언어의학회지 대한후두음성언어의학회지 제29권 제1호

발행연도: 2018.1

수록면: 30 - 36 (7page)

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연구주제

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연구배경

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연구방법

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연구결과

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Background and Objectives : The effect of palliative injection laryngoplasty in cancer-related unilateral vocal cord paralysis patients on voice and swallowing function is uncertain and there are few previous studies of its suitability, benefits as a palliative treatment option. The purpose of this study is to confirm the objective results of voice and swallowing function after palliative office-based hyaluronic acid injection laryngoplasty in cancer-related unilateral vocal cord paralysis patients. Materials and Method : 36 patients who had unilateral vocal cord paralysis from non-thyroidal, extralaryngeal neoplasms were included in this study. To evaluate the clinical outcome, we analyzed perceptual GRBAS grading, acoustic analysis, aerodynamic study, Electroglottography (EGG), Voice Handicap Index (VHI-30) about voice function and disability rating scale (DRS), gastric tube dependency, aspiration pneumonia about swallowing function and 36-Item Short Form Survey version 2 (SF-36v2) about quality of life. Results : In GRBAS scale, G (p<0.001), R (p=0.004), B (p=0.001), A (p=0.011), and S (p=0.007) showed significant improvement. Jitter, shimmer, speaking fundamental frequency, maximal phonation time, VHI-30, DRS score, gastric tube dependency, aspiration pneumonia, and SF-36v2 were significantly improved after injection (p=0.016, p=0.011, p=0.045, p=0.005, p<0.001, p<0.001 p=0.003, p<0.001, and p<0.001 respectively). Conclusion : From this study we concluded office-based hyaluronic acid injection can be used as a useful palliative treatment option in cancer-related ill patients with unilateral vocal cord paralysis. Palliative hyaluronic acid injection laryngoplasty avoids the need for tube feeding, thus reducing the risk of aspiration pneumonia. These outcomes are accompanied by significant improvement in voice quality.

#성대 마비 #악성 종양 #고식적 성대 주입 성형술

참고문헌 (20)

참고문헌 신청

Sun DI / 2013 / Injection laryngoplasty / Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 24(2):88~95

Benninger MS / 1994 / Evaluation and treatment of the unilateral paralyzed vocal fold / Otolaryngol Head Neck Surg 111(4):497~508

Benninger MS / 1998 / Changing etiology of vocal fold immobility / Laryngoscope 108(9):1346~1350

Soriano RG / 2016 / In-Office Hyaluronate Injection Laryngoplasty as Palliative Treatment for Unilateral Vocal Fold Paralysis / ORL J Otorhinolaryngol Relat Spec 78(4):187~192

Choi HS / 2007 / Medialization thyroplasty with silastic-decision making & practical points / Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics 18(1):7~10

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