암컷 랫드에서 Methylcyclohexane의 단회 경구투여 독성시험

김성환; 임정현; 신인식; 문창종; 김성호; 신동호; 김종춘

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자료유형: 학술저널

저자정보: 김성환 (전남대학교 수의과 대학) 임정현 (전남대학교 수의과 대학) 신인식 (한국한의학연구원 한약EBM연구센터) 문창종 (전남대학교 수의과 대학) 김성호 (전남대학교 수의과 대학) 신동호 (전남대학교 수의과 대학) 김종춘 (전남대학교 수의과 대학)

저널정보: 한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제21권 제1호

발행연도: 2011.1

수록면: 33 - 39 (7page)

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The present study was carried out to investigate the potential acute toxicity of methylcyclohexane (MCH) by a single oral dose in female rats. The test chemical was administered once by gavage to female rats at dose levels 0, 1,250, 2,500, and 5,000 mg/kg. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period following the administration. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem and histopathological examinations were performed. Treatment-related clinical signs, as evidenced by depression, soft feces, decreased locomotion activity, solid perineal region, crouching position, and anorexia were observed in all treatment groups in a dose-dependent manner. At the dose level of 5,000 mg/kg, decreased or suppressed body weight gain was found during the study period. At the scheduled necropsy, one case of congestion of the intestine and an increase in the weights of liver and kidney were observed in the 5,000 mg/kg group. Histopathological examinations exhibited an increased incidence of glomerular atrophy, congestion/hemorrhage, and focal degeneration/necrosis in the liver and an increased incidence of congestion, and inflammatory cell infiltration in the kidney. On the basis of the results, it was concluded that a single oral administration of MCH resulted in some adverse effects on clinical sign, body weight gain, and organ weight and histopathology in the liver and kidney in female rats. In the experimental conditions, the minimal lethal dose ($LD_{10}$) of MCH was greater than 5,000 mg/kg.

#methylcyclohexane #acute toxicity #lethal dose #female rats

참고문헌 (22)

참고문헌 신청

김현영 / 2006 / 메틸사이클로핵산 (methylcyclohexane)의 흡입독성과 유해성 평가 / 환경독성보건학회지 21(2):173~184

노동부 / 2007 / 산업안전 보건기준에 관한 규칙 별표 7 관리대상물질의 종류

한국산업안전공단 / 2005 / 물질안전보건자료(MSDS)

ACGIH (American Conference of Governmental Industrial Hygienists) / 2001 / Methylcyclohexane. Documentation of the Threshold Limit Values and Biological Exposure Indices / ACGIH

ACGIH (American Conference of Governmental Industrial Hygienists) / 2007 / Methylcyclohexane. Documentation of the Threshold Limit Values and Biological Exposure Indices., 7th ed / ACGIH