시너(thinner)의 물리화학적 특성과 랫트의 생식기에 미치는 영향 연구

김현영; 이성배; 한정희; 김태균; 이정석; 강민구; 이채관

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자료유형: 학술저널

저자정보: 김현영 (산업안전보건연구원 화학물질안전보건센터) 이성배 (산업안전보건연구원 화학물질안전보건센터) 한정희 (산업안전보건연구원 화학물질안전보건센터) 김태균 (산업안전보건연구원 화학물질안전보건센터) 이정석 (산업안전보건연구원 화학물질안전보건센터) 강민구 (산업안전보건연구원 화학물질안전보건센터) 이채관 (인제대학교 산업의학연구소)

저널정보: 한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제18권 제3호

발행연도: 2008.1

수록면: 224 - 238 (15page)

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The aim of this study is to confirm the physicochemical property and hazard of thinner (012), which is a diluent of enamel paint used for floor coating for waterproofing and oil painting for the outer wall. The literatures of physicochemical property and hazard of thinner were surveyed and its physicochemical property were evaluated. And then, the inhalation toxicity of thinner affecting the central nervous system and reproductive organs in rats were examined by subchronic (6 h./day. 5 days/ week for 13 weeks) inhalation test. 1) According to the 13-week subchronic inhalation test, there were no significant changes in clinical test and body weight. However, a significant evidence of toxicity was observed in the hematological test and organ weight such as heart, kidney, liver and brain (p<0.01) in the 200 ppm and 1,000 ppm exposure groups in a dose response manner. In the histopathology analysis, there were no significant evidence of toxicity. Therefore, thinner was not classified as an organ targeted toxic agent. In case of Harmfulness, it could be classified as a chronic toxic agent 3($500<LC_{50}{\leq}2,500$ ppm/4hr, rat). 2) The reproductive toxicity such as extension of the period of estrous cycle, reduction of serum estradiol concentration and increase of frequency of the abnormal sperm was observed in the 1,000 ppm exposed animals. 3) The result of the physicochemical property of the test material showed that the specific gravity was 0.793, boiling point $155.8^{\circ}C$, steam pressure 2.1 kPa, ignition point $34.5^{\circ}C$, and spontaneous ignition point $280^{\circ}C$. The endothermic and exothermic values were 371.4 J/g and 159.1 J/g. respectively. The explosion limit was 214 mg/l. These data showed that thinner could be classified as an explosion agent level 1.2 and ignitive liquid agent 3 ($23-60^{\circ}C$) according to the notification No. 2008-1 of the Labor Ministry, "Classifying Standard of Chemical Materials."

#thinner #inhalation toxicity #reproductive toxicity #hazard #physicochemical property

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