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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 237 - 252 (16page)
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초록· 키워드
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Objectives: This study was conducted in order to improve the current understanding of rare earths(RE) and to provide supporting data for establishing occupational health policies by reviewing the toxicological data and issues caused by the use of RE compounds in various fields. Methods: To evaluate the potential toxicity of RE from the viewpoint of occupational health, we summarized extensive reviews of relevant articles in the toxicology(animals and cells), occupational health and safety, and epidemiologic literature. Results: Although occupational RE exposure occurs extensively from ore mining and refining to end users in various industrial applications, epidemiologic study has not been performed among workers up to now. Bioaccumulation and adverse effects of RE have also been mentioned in ore mining regions and nearby residences, but safety standards for each process are insufficient. Moreover, because new commercial recycling technology will soon be applied to various industries, regulation and policies are needed for preventing abuse of recycling. In the results of animal toxicity for a few REs(mostly cerium, lanthanum, and gadolinium), toxicities of liver, lung, blood, and the nervous system were identified due to oxidative stress, but study of long-term RE exposure is required. Understanding the dual effect for RE and discovery of biomarkers pose a scientific challenge in further mechanism studies. Conclusions: In the future, additional hazard evaluation based on animal experiments is required, alongside continuous research for developing analytical methods and discovering biomarkers. Finally, RE occupational health and safety management needs to be integrated into the sustainable use of these materials.
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참고문헌 (72)
참고문헌 신청
Aalapati S / 2014 / Toxicity and bio-accumulation of inhaled cerium oxide nanoparticles in CD1 mice / Nanotoxicology 8:786~798
Bustamante P / 2005 / Subcellular and body distributions of 17 trace elements in the variegated scallop Chlamys varia from the French coast of the Bay of Biscay / Sci Total Environ 337:59~73
Carpenter D / 2015 / Uptake and effects of six rare earth elements(REEs) on selected native and crop species growing in contaminated soils / PLoS One 10(6):e0129936
Cassee FR / 2012 / The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice / Environ Res 115:1~10
Cassee FR / 2011 / Exposure, health and ecological effects review of engineered nanoscale cerium and cerium oxide associated with its use as a fuel additive / Crit Rev Toxicol 41:213~229
Bustamante P / 2005 / Subcellular and body distributions of 17 trace elements in the variegated scallop Chlamys varia from the French coast of the Bay of Biscay / Sci Total Environ 337:59~73
Carpenter D / 2015 / Uptake and effects of six rare earth elements(REEs) on selected native and crop species growing in contaminated soils / PLoS One 10(6):e0129936
Cassee FR / 2012 / The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice / Environ Res 115:1~10
Cassee FR / 2011 / Exposure, health and ecological effects review of engineered nanoscale cerium and cerium oxide associated with its use as a fuel additive / Crit Rev Toxicol 41:213~229
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