지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 336 - 344 (9page)
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초록· 키워드
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Objectives: This study was performed to assay the effect of neodymium oxide on the generation of reactive oxygen species and DNA oxidative damage by intratracheal instillation. Methods: Two groups of rats were exposed to neodymium oxide($Nd_2O_3$) via intratracheal instillation with doses of 0.5 mg and 2.0 mg, respectively. At two days and at 12 weeks after exposure, the contents of neodymium oxide in the lung, liver, kidney, heart and brain, leukocyte, olive tail moment, ROS, RNS, lactate dehydrogenase, albumin, cytokine and MDA from BALF were measured. Results: Neodymium oxide contents in the liver, kidney, heart, and brain were detected at less than $1{\mu}g/g$ tissue concentration. However, in the lungs at four weeks the highest amount were detected and then found to be drastically reduced at 12 weeks. ROS and RNS in bronchoalveolar lavage increased in concentration dependently at two days, four weeks and 12 weeks after neodymium oxide instillation. However, ROS and RNS decreased with the passage of time. At two days the total number of WBC in BALF in the high concentration group was significantly increased, and at four weeks the total number of WBC were significantly increased in the low and high concentration groups(p<0.01). At two days after exposure, the LDH of the low and high concentration groups was significantly increased. At 12 weeks, only the LDH of the high concentration group was significantly increased compared to in the control group(p<0.01). As a result of Comet assay, after two days, damage to the DNA of the low and high concentration groups was observed. Conclusions: Intratracheal instillation of neodymium oxide induces the generation of ROS and DNA damage in rats.
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참고문헌 (18)
참고문헌 신청
Anand MJ / 1995 / Clastogenicity of lanthanides:induction of chromosomal aberration in bone marrow cells of mice in vivo 341(3):193~197
Bellmann B / 1997 / Investigation of the biodurability of man made vitreous fibers ion rat lungs / Environ Health perspect 102(5):185~189
Carter JM / 2006 / A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black / J Occup Environ Med 48(12):1265~1278
Edilberto B / 2004 / Pulmonary Responses of Mice, Rats, and Hamsters to Subchronic Inhalation of Ultrafine Titanium Dioxide Particles / TOXICOLOGICAL SCIENCES 77:347~357
Farmer EE / 2007 / Reactive electrophile species / Curr. Opin. Plant Biol 10(4):380~386
Bellmann B / 1997 / Investigation of the biodurability of man made vitreous fibers ion rat lungs / Environ Health perspect 102(5):185~189
Carter JM / 2006 / A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black / J Occup Environ Med 48(12):1265~1278
Edilberto B / 2004 / Pulmonary Responses of Mice, Rats, and Hamsters to Subchronic Inhalation of Ultrafine Titanium Dioxide Particles / TOXICOLOGICAL SCIENCES 77:347~357
Farmer EE / 2007 / Reactive electrophile species / Curr. Opin. Plant Biol 10(4):380~386
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